Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 30,356	$ 28,785	$ 89,614	$ 84,626
Income tax benefit from share-based compensation expense	(3,436)	(4,106)	(10,106)	(12,246)
Total share-based compensation expense, net of tax	26,920	24,679	79,508	72,380
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	20,974	20,302	62,590	61,357
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	7,463	6,498	21,511	17,917
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 1,919	$ 1,985	$ 5,513	$ 5,352