Revenues - Summary of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Disaggregation of Revenue [Line Items]
Total revenues	$ 600,888	$ 537,702	$ 1,698,050	$ 1,580,021
United States
Disaggregation of Revenue [Line Items]
Total revenues	548,410	492,366	1,542,990	1,436,160
Europe
Disaggregation of Revenue [Line Items]
Total revenues	45,778	35,037	125,229	106,956
All other
Disaggregation of Revenue [Line Items]
Total revenues	6,700	10,299	29,831	36,905
Product sales, net
Disaggregation of Revenue [Line Items]
Total revenues	596,949	532,321	1,685,357	1,559,075
Xyrem
Disaggregation of Revenue [Line Items]
Total revenues	447,809	425,644	1,302,492	1,207,173
Defitelio/defibrotide
Disaggregation of Revenue [Line Items]
Total revenues	50,241	37,604	140,387	125,159
Erwinaze/Erwinase
Disaggregation of Revenue [Line Items]
Total revenues	20,145	34,024	90,560	122,545
Vyxeos
Disaggregation of Revenue [Line Items]
Total revenues	30,825	29,581	90,113	89,886
Zepzelca
Disaggregation of Revenue [Line Items]
Total revenues	36,941	0	36,941	0
Sunosi
Disaggregation of Revenue [Line Items]
Total revenues	9,116	987	19,618	987
Other
Disaggregation of Revenue [Line Items]
Total revenues	1,872	4,481	5,246	13,325
Royalties and contract revenues
Disaggregation of Revenue [Line Items]
Total revenues	$ 3,939	$ 5,381	$ 12,693	$ 20,946