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Certain Balance Sheet Items - Accrued Liabilities (Details) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Certain Balance Sheet Items [Abstract]    
Rebates and other sales deductions $ 113,062 $ 96,860
Employee compensation and benefits 76,890 80,531
Sales returns reserve 13,574 3,462
Current portion of operating lease liabilities 13,078 12,728
Royalties 10,186 6,931
Inventory-related accruals 9,318 7,816
Consulting and professional services 8,430 7,665
Derivative instrument liabilities 8,364 1,037
Accrued interest 7,762 7,540
Clinical trial accruals 7,614 3,141
Selling and marketing accruals 7,721 10,946
Accrued collaboration expenses 730 2,494
Accrued construction-in-progress 474 3,015
Other 24,868 25,520
Total accrued liabilities $ 302,071 $ 269,686