Share-Based Compensation - (Tables)

9 Months Ended

Sep. 30, 2020

Share-based Payment Arrangement [Abstract]

Schedule of Share-Based Compensation Expense Related to Share Options, RSUs and Grants Under ESPP

Share-based compensation expense related to share options, RSUs and grants under our ESPP was as follows (in thousands): 

	Three Months Ended September 30,				Nine Months Ended September 30,
	2020		2019		2020		2019
Selling, general and administrative	$	20,974	$	20,302	$	62,590	$	61,357
Research and development	7,463		6,498		21,511		17,917
Cost of product sales	1,919		1,985		5,513		5,352
Total share-based compensation expense, pre-tax	30,356		28,785		89,614		84,626
Income tax benefit from share-based compensation expense	(3,436)		(4,106)		(10,106)		(12,246)
Total share-based compensation expense, net of tax	$	26,920	$	24,679	$	79,508	$	72,380

Schedule of Weighted-Average Assumptions Used in Black-Scholes Option Pricing Model which was Used to Estimate Grant Date Fair Value per Share

The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted: 

	Three Months Ended September 30,						Nine Months Ended September 30,
	2020			2019			2020			2019
Shares underlying options granted (in thousands)	159			198			803			1,597
Grant date fair value	$	37.75		$	40.62		$	34.43		$	42.32
Black-Scholes option pricing model assumption information:
Volatility	36		%	33		%	33		%	32		%
Expected term (years)	4.6			4.5			4.6			4.5
Range of risk-free rates	0.2-0.3%			1.5-1.7%			0.2-1.6%			1.5-2.5%
Expected dividend yield	—		%	—		%	—		%	—		%

Schedule of Restricted Stock Unit activity

The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2020		2019		2020		2019
RSUs granted (in thousands)	160		80		1,248		642
Grant date fair value	$	123.79	$	135.90	$	114.80	$	138.50