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Share-Based Compensation
9 Months Ended
Sep. 30, 2020
Share-based Payment Arrangement [Abstract]  
Share-Based Compensation Share-Based Compensation
Share-based compensation expense related to share options, RSUs and grants under our ESPP was as follows (in thousands): 
Three Months Ended
September 30,
Nine Months Ended
September 30,
2020201920202019
Selling, general and administrative$20,974 $20,302 $62,590 $61,357 
Research and development7,463 6,498 21,511 17,917 
Cost of product sales1,919 1,985 5,513 5,352 
Total share-based compensation expense, pre-tax30,356 28,785 89,614 84,626 
Income tax benefit from share-based compensation expense(3,436)(4,106)(10,106)(12,246)
Total share-based compensation expense, net of tax$26,920 $24,679 $79,508 $72,380 
Share Options
The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted: 
Three Months Ended
September 30,
Nine Months Ended
September 30,
2020201920202019
Shares underlying options granted (in thousands)159 198 803 1,597 
Grant date fair value$37.75 $40.62 $34.43 $42.32 
Black-Scholes option pricing model assumption information:
Volatility36 %33 %33 %32 %
Expected term (years)4.64.54.64.5
Range of risk-free rates
0.2-0.3%
1.5-1.7%
0.2-1.6%
1.5-2.5%
Expected dividend yield— %— %— %— %
Restricted Stock Units
The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2020201920202019
RSUs granted (in thousands)160 80 1,248 642 
Grant date fair value$123.79 $135.90 $114.80 $138.50 
The fair value of RSUs is determined on the date of grant based on the market price of our ordinary shares on that date. The fair value of RSUs is expensed ratably over the vesting period, generally over four years.
As of September 30, 2020, compensation cost not yet recognized related to unvested share options and RSUs was $66.8 million and $152.6 million, respectively, which is expected to be recognized over a weighted-average period of 2.5 years and 2.9 years, respectively.