Share-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 30,604	$ 28,289	$ 59,258	$ 55,841
Income tax benefit from share-based compensation expense	(2,924)	(4,473)	(6,670)	(8,140)
Total share-based compensation expense, net of tax	27,680	23,816	52,588	47,701
Selling, general and administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	21,020	20,685	41,616	41,055
Research and development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	7,663	5,896	14,048	11,419
Cost of product sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Total share-based compensation expense, pre-tax	$ 1,921	$ 1,708	$ 3,594	$ 3,367