Revenues - Summary of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Disaggregation of Revenue [Line Items]
Total revenues	$ 562,436	$ 534,133	$ 1,097,162	$ 1,042,319
United States
Disaggregation of Revenue [Line Items]
Total revenues	516,097	480,932	994,580	943,794
Europe
Disaggregation of Revenue [Line Items]
Total revenues	37,895	36,518	79,451	71,919
All other
Disaggregation of Revenue [Line Items]
Total revenues	8,444	16,683	23,131	26,606
Product sales, net
Disaggregation of Revenue [Line Items]
Total revenues	558,203	523,423	1,088,408	1,026,754
Xyrem
Disaggregation of Revenue [Line Items]
Total revenues	446,808	413,212	854,683	781,529
Defitelio/defibrotide
Disaggregation of Revenue [Line Items]
Total revenues	42,714	46,055	90,146	87,555
Erwinaze/Erwinase
Disaggregation of Revenue [Line Items]
Total revenues	32,683	27,622	70,415	88,521
Vyxeos
Disaggregation of Revenue [Line Items]
Total revenues	26,568	31,362	59,288	60,305
Sunosi
Disaggregation of Revenue [Line Items]
Total revenues	8,578	0	10,502	0
Other
Disaggregation of Revenue [Line Items]
Total revenues	852	5,172	3,374	8,844
Royalties and contract revenues
Disaggregation of Revenue [Line Items]
Total revenues	$ 4,233	$ 10,710	$ 8,754	$ 15,565