CONDENSED CONSOLIDATED STATEMENTS OF INCOME (LOSS) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenues:
Total revenues	$ 562,436	$ 534,133	$ 1,097,162	$ 1,042,319
Operating expenses:
Cost of product sales (excluding amortization of acquired developed technologies)	28,008	27,676	56,665	61,182
Selling, general and administrative	191,406	176,014	399,806	343,961
Research and development	78,922	62,384	165,029	122,489
Intangible asset amortization	62,974	61,576	125,821	118,461
Acquired in-process research and development	3,000	2,200	205,250	58,200
Impairment charge	0	0	136,139	0
Total operating expenses	364,310	329,850	1,088,710	704,293
Income from operations	198,126	204,283	8,452	338,026
Interest expense, net	(26,210)	(18,234)	(44,706)	(36,156)
Foreign exchange loss	(464)	(1,933)	(1,596)	(2,544)
Income (loss) before income tax provision (benefit) and equity in loss of investees	171,452	184,116	(37,850)	299,326
Income tax provision (benefit)	54,754	(78,650)	3,467	(49,534)
Equity in loss of investees	1,897	868	1,715	1,761
Net income (loss)	$ 114,801	$ 261,898	$ (43,032)	$ 347,099
Net income (loss) per ordinary share:
Basic (in dollars per share)	$ 2.07	$ 4.62	$ (0.77)	$ 6.09
Diluted (in dollars per share)	$ 2.06	$ 4.56	$ (0.77)	$ 6.01
Weighted-average ordinary shares used in per share calculations - basic (in shares)	55,413	56,707	55,684	56,955
Weighted-average ordinary shares used in per share calculations - diluted (in shares)	55,864	57,427	55,684	57,753
Product sales, net
Revenues:
Total revenues	$ 558,203	$ 523,423	$ 1,088,408	$ 1,026,754
Royalties and contract revenues
Revenues:
Total revenues	$ 4,233	$ 10,710	$ 8,754	$ 15,565