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Share-Based Compensation
6 Months Ended
Jun. 30, 2020
Share-based Payment Arrangement [Abstract]  
Share-Based Compensation Share-Based Compensation
Share-based compensation expense related to share options, RSUs and grants under our ESPP was as follows (in thousands): 
 
Three Months Ended
June 30,
 
Six Months Ended
June 30,
 
2020
 
2019
 
2020
 
2019
Selling, general and administrative
$
21,020

 
$
20,685

 
$
41,616

 
$
41,055

Research and development
7,663

 
5,896

 
14,048

 
11,419

Cost of product sales
1,921

 
1,708

 
3,594

 
3,367

Total share-based compensation expense, pre-tax
30,604

 
28,289

 
59,258

 
55,841

Income tax benefit from share-based compensation expense
(2,924
)
 
(4,473
)
 
(6,670
)
 
(8,140
)
Total share-based compensation expense, net of tax
$
27,680

 
$
23,816

 
$
52,588

 
$
47,701


Share Options
The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted: 
 
Three Months Ended
June 30,
 
Six Months Ended
June 30,
 
2020
 
2019
 
2020
 
2019
Shares underlying options granted (in thousands)
79

 
102

 
644

 
1,399

Grant date fair value
$
33.29

 
$
38.95

 
$
33.61

 
$
42.56

Black-Scholes option pricing model assumption information:
 
 
 
 
 
 
 
Volatility
36
%
 
31
%
 
32
%
 
32
%
Expected term (years)
4.6

 
4.5

 
4.6

 
4.5

Range of risk-free rates
0.3-0.4%

 
1.8-2.3%

 
0.3-1.6%

 
1.8-2.5%

Expected dividend yield
%
 
%
 
%
 
%

Restricted Stock Units
The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:
 
Three Months Ended
June 30,
 
Six Months Ended
June 30,
 
2020
 
2019
 
2020
 
2019
RSUs granted (in thousands)
129

 
42

 
1,088

 
561

Grant date fair value
$
108.20

 
$
132.73

 
$
113.48

 
$
138.87


The fair value of RSUs is determined on the date of grant based on the market price of our ordinary shares on that date. The fair value of RSUs is expensed ratably over the vesting period, generally over four years.
As of June 30, 2020, compensation cost not yet recognized related to unvested share options and RSUs was $74.5 million and $159.4 million, respectively, which is expected to be recognized over a weighted-average period of 2.6 years and 3.0 years, respectively.