Revenues - Summary of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Disaggregation of Revenue [Line Items]
Total revenues	$ 534,726	$ 508,186
United States
Disaggregation of Revenue [Line Items]
Total revenues	478,483	462,862
Europe
Disaggregation of Revenue [Line Items]
Total revenues	41,556	35,401
All other
Disaggregation of Revenue [Line Items]
Total revenues	14,687	9,923
Product sales, net
Disaggregation of Revenue [Line Items]
Total revenues	530,205	503,331
Xyrem
Disaggregation of Revenue [Line Items]
Total revenues	407,875	368,317
Erwinaze/Erwinase
Disaggregation of Revenue [Line Items]
Total revenues	37,732	60,899
Defitelio/defibrotide
Disaggregation of Revenue [Line Items]
Total revenues	47,432	41,500
Vyxeos
Disaggregation of Revenue [Line Items]
Total revenues	32,720	28,943
Sunosi
Disaggregation of Revenue [Line Items]
Total revenues	1,924	0
Other
Disaggregation of Revenue [Line Items]
Total revenues	2,522	3,672
Royalties and contract revenues
Disaggregation of Revenue [Line Items]
Total revenues	$ 4,521	$ 4,855