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Certain Balance Sheet Items - Accrued Liabilities (Details) - USD ($)
$ in Thousands
Mar. 31, 2020
Dec. 31, 2019
Certain Balance Sheet Items [Abstract]    
Rebates and other sales deductions $ 121,369 $ 96,860
Employee compensation and benefits 52,080 80,290
Current portion of operating lease liabilities 12,357 12,728
Derivative instrument liabilities 8,663 1,037
Selling and marketing accruals 8,443 11,299
Inventory-related accruals 7,706 7,816
Sales returns reserve 4,519 3,462
Accrued collaboration expenses 3,865 2,494
Professional fees 3,495 4,718
Royalties 2,654 6,931
Accrued interest 2,520 7,386
Clinical trial accruals 2,473 2,551
Accrued construction-in-progress 256 1,564
Other 30,641 28,737
Total accrued liabilities $ 261,041 $ 267,873