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Certain Balance Sheet Items - Accrued Liabilities (Details) - USD ($)
$ in Thousands
Jun. 30, 2019
Jan. 01, 2019
Dec. 31, 2018
Certain Balance Sheet Items [Abstract]      
Rebates and other sales deductions $ 79,134   $ 86,495
Employee compensation and benefits 49,050   58,543
Clinical trial accruals 9,780   5,904
Current portion of operating lease liabilities 8,722   0
Accrued interest 7,531   7,407
Accrued construction-in-progress 7,669   1,065
Inventory-related accruals 7,130   8,753
Selling and marketing accruals 6,275   6,780
Royalties 5,101   2,679
Professional fees 4,083   2,333
Sales returns reserve 2,395   2,510
Derivative instrument liabilities 270   1,460
Accrued loss contingency 0   58,154
Other 31,611   22,804
Total accrued liabilities $ 218,751 $ 273,052 $ 264,887