Certain Balance Sheet Items - (Tables)

6 Months Ended

Jun. 30, 2019

Certain Balance Sheet Items [Abstract]

Property and Equipment

Property, plant and equipment consisted of the following (in thousands):

	June 30, 2019			December 31, 2018
Land and buildings	$	46,636		$	46,650
Construction-in-progress	33,483			51,243
Leasehold improvements	32,572			33,273
Manufacturing equipment and machinery	26,859			25,837
Computer software	18,193			19,062
Computer equipment	14,341			13,679
Furniture and fixtures	7,759			8,155
Build-to-suit facility	—			52,067
Subtotal	179,843			249,966
Less accumulated depreciation and amortization	(52,660		)	(49,608		)
Property, plant and equipment, net	$	127,183		$	200,358

Accrued Liabilities

Accrued liabilities consisted of the following (in thousands):

	June 30, 2019		December 31, 2018
Rebates and other sales deductions	$	79,134	$	86,495
Employee compensation and benefits	49,050		58,543
Clinical trial accruals	9,780		5,904
Current portion of operating lease liabilities	8,722		—
Accrued interest	7,531		7,407
Accrued construction-in-progress	7,669		1,065
Inventory-related accruals	7,130		8,753
Selling and marketing accruals	6,275		6,780
Royalties	5,101		2,679
Professional fees	4,083		2,333
Sales returns reserve	2,395		2,510
Derivative instrument liabilities	270		1,460
Accrued loss contingency	—		58,154
Other	31,611		22,804
Total accrued liabilities	$	218,751	$	264,887