Revenues - Summary of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Disaggregation of Revenue [Line Items]
Total revenues	$ 1,890,922	$ 1,618,693	$ 1,487,973
United States
Disaggregation of Revenue [Line Items]
Total revenues	1,727,576	1,463,457	1,355,921
Europe
Disaggregation of Revenue [Line Items]
Total revenues	125,911	125,624	108,301
All other
Disaggregation of Revenue [Line Items]
Total revenues	37,435	29,612	23,751
Product sales, net
Disaggregation of Revenue [Line Items]
Total revenues	1,869,473	1,601,399	1,477,261
Xyrem
Disaggregation of Revenue [Line Items]
Total revenues	1,404,866	1,186,699	1,107,616
Erwinaze/Erwinase
Disaggregation of Revenue [Line Items]
Total revenues	174,739	197,340	200,678
Defitelio/defibrotide
Disaggregation of Revenue [Line Items]
Total revenues	149,448	133,650	108,952
Vyxeos
Disaggregation of Revenue [Line Items]
Total revenues	100,835	33,790	0
Prialt
Disaggregation of Revenue [Line Items]
Total revenues	20,839	27,361	29,120
Other
Disaggregation of Revenue [Line Items]
Total revenues	18,746	22,559	30,895
Royalties and contract revenues
Disaggregation of Revenue [Line Items]
Total revenues	$ 21,449	$ 17,294	$ 10,712