Goodwill and Intangible Assets - Schedule of Gross Carrying Amounts and Net Book Values of Intangible Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Finite-Lived and Indefinite Lived Intangible Assets [Line Items]
Gross Carrying Amount	$ 3,236,894	$ 3,408,566
Accumulated Amortization	(647,565)	(578,017)
Total	2,589,329	2,830,549
Intangible assets, gross	3,378,899	3,557,144
Intangible assets, net	2,731,334	2,979,127
Acquired IPR&D assets
Finite-Lived and Indefinite Lived Intangible Assets [Line Items]
Acquired IPR&D assets	$ 142,005	148,578
Acquired developed technologies
Finite-Lived and Indefinite Lived Intangible Assets [Line Items]
Remaining Weighted- Average Useful Life (In years)	13 years 11 months 6 days
Gross Carrying Amount	$ 3,110,641	3,392,832
Accumulated Amortization	(632,413)	(562,473)
Total	2,478,228	2,830,359
Contract-Based Intangible Assets
Finite-Lived and Indefinite Lived Intangible Assets [Line Items]
Gross Carrying Amount	111,101	0
Accumulated Amortization	0	0
Total	$ 111,101	0
Manufacturing contracts
Finite-Lived and Indefinite Lived Intangible Assets [Line Items]
Remaining Weighted- Average Useful Life (In years)	0 years
Gross Carrying Amount	$ 12,256	12,824
Accumulated Amortization	(12,256)	(12,634)
Total	$ 0	190
Trademarks
Finite-Lived and Indefinite Lived Intangible Assets [Line Items]
Remaining Weighted- Average Useful Life (In years)	0 years
Gross Carrying Amount	$ 2,896	2,910
Accumulated Amortization	(2,896)	(2,910)
Total	$ 0	$ 0