Quarterly Financial Data (Unaudited)

12 Months Ended

Dec. 31, 2018

Quarterly Financial Information Disclosure [Abstract]

The following interim financial information presents our 2018 and 2017 results of operations on a quarterly basis (in thousands, except per share amounts):



	2018
	March 31		June 30		September 30		December 31
Revenues	$	444,613	$	500,479	$	469,373	$	476,457
Gross margin (1)	406,928		461,381		438,623		440,997
Net income	45,991		92,321		149,316		159,470
Net income per ordinary share, basic	0.77		1.53		2.47		2.69
Net income per ordinary share, diluted	0.75		1.50		2.41		2.64



	2017
	March 31		June 30		September 30		December 31
Revenues	$	376,053	$	394,386	$	411,855	$	436,399
Gross margin (1)	348,613		360,983		376,768		404,847
Net income	86,511		105,604		63,526		232,207
Net income per ordinary share, basic	1.44		1.76		1.06		3.87
Net income per ordinary share, diluted	1.41		1.72		1.03		3.79

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(1)	Gross margin is computed by subtracting cost of product sales (excluding amortization of intangible assets) from product sales, net.

The interim financial information above includes the following items:


•	Estimated loss contingency of $57.0 million in the first quarter of 2018;


•	Impairment charges and disposal costs of $44.0 million in the second quarter of 2018;


•	Upfront and milestone payments of $11.0 million in the first quarter of 2018 and $75.0 million and $26.5 million in the third and fourth quarters of 2017, respectively;


•	Expenses related to certain legal proceedings and restructuring of $6.0 million in the first quarter of 2017; and


•	A net expense of $2.9 million and a net benefit of $10.3 million in the third and fourth quarters of 2018, respectively, and a net benefit of $148.8 million in the fourth quarter of 2017 in respect of the impact of the U.S. Tax Act.