Certain Balance Sheet Items (Tables)

6 Months Ended

Jun. 30, 2018

Certain Balance Sheet Items [Abstract]

Property and Equipment

Property, plant and equipment consisted of the following (in thousands):

	June 30, 2018			December 31, 2017
Build-to-suit facility	$	52,222		$	51,721
Land and buildings	46,744			46,729
Construction-in-progress	37,352			21,738
Leasehold improvements	30,417			28,779
Manufacturing equipment and machinery	24,558			23,586
Computer software	19,498			19,969
Computer equipment	13,764			12,814
Furniture and fixtures	7,083			5,947
Subtotal	231,638			211,283
Less accumulated depreciation and amortization	(43,552		)	(41,203		)
Property, plant and equipment, net	$	188,086		$	170,080

Accrued Liabilities

Accrued liabilities consisted of the following (in thousands):

	June 30, 2018		December 31, 2017
Rebates and other sales deductions	$	86,921	$	81,368
Estimated loss contingency	57,353		—
Employee compensation and benefits	43,824		54,930
Royalties	7,614		8,058
Accrued interest	7,430		7,297
Inventory-related accruals	6,068		3,002
Clinical trial accruals	5,606		2,181
Derivative instrument liabilities	5,400		5,409
Selling and marketing accruals	4,221		3,189
Professional fees	3,596		3,213
Sales returns reserve	2,696		3,651
Accrued construction-in-progress	1,767		2,827
Other	26,298		23,654
Total accrued liabilities	$	258,794	$	198,779