Certain Balance Sheet Items - Accrued Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Certain Balance Sheet Items [Abstract]
Rebates and other sales deductions	$ 70,264	$ 67,454
Employee compensation and benefits	32,873	35,595
Sales returns reserve	5,706	6,110
Royalties	5,396	4,211
Inventory-related accruals	5,236	1,017
Clinical trial accruals	4,449	1,601
Professional fees	3,655	3,038
Accrued interest	3,475	4,043
Accrued construction-in-progress	1,116	1,637
Contract claim settlement	0	18,000
Other	25,452	21,364
Total accrued liabilities	$ 157,622	$ 164,070