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Goodwill and Intangible Assets - Gross Carrying Amounts and Net Book Values of Intangible Assets (Details) - USD ($)
$ in Thousands
6 Months Ended 12 Months Ended
Mar. 30, 2016
Jun. 30, 2016
Dec. 31, 2015
Finite-Lived Intangible Assets [Line Items]      
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 1,545,297 $ 1,335,903
Accumulated Amortization - Finite-Lived Intangible Assets   (382,002) (332,602)
Total   1,163,295 1,003,301
Indefinite-lived Intangible Assets [Line Items]      
Gross Carrying Amount - Total Intangible Assets   1,682,763 1,518,208
Net Book Value - Total Intangible Assets   1,300,761 1,185,606
Acquired IPR&D assets [Member]      
Indefinite-lived Intangible Assets [Line Items]      
In-process research and development   137,466 182,305
Increase (decrease) in indefinite-lived intangible assets $ (48,400)    
Sigma-Tau Milestone Payment [Member]      
Indefinite-lived Intangible Assets [Line Items]      
Increase (decrease) in indefinite-lived intangible assets   $ 150,000  
Acquired developed technologies [Member]      
Finite-Lived Intangible Assets [Line Items]      
Remaining Weighted- Average Useful Life (In years)   11 years 9 months  
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 1,530,546 1,321,324
Accumulated Amortization - Finite-Lived Intangible Assets   (371,876) (324,044)
Total   $ 1,158,670 997,280
Increase in finite-lived intangible assets $ 48,400    
Acquired developed technologies [Member] | Defitelio [Member]      
Finite-Lived Intangible Assets [Line Items]      
Remaining Weighted- Average Useful Life (In years)   14 years  
Manufacturing contracts [Member]      
Finite-Lived Intangible Assets [Line Items]      
Remaining Weighted- Average Useful Life (In years)   1 year 7 months  
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 11,865 11,697
Accumulated Amortization - Finite-Lived Intangible Assets   (7,240) (5,676)
Total   $ 4,625 6,021
Trademarks [Member]      
Finite-Lived Intangible Assets [Line Items]      
Remaining Weighted- Average Useful Life (In years)   0 years  
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 2,886 2,882
Accumulated Amortization - Finite-Lived Intangible Assets   (2,886) (2,882)
Total   $ 0 $ 0