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Goodwill and Intangible Assets - Gross Carrying Amounts and Net Book Values of Intangible Assets (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 30, 2016
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Finite-Lived Intangible Assets [Line Items]        
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 1,567,764   $ 1,335,903
Accumulated Amortization - Finite-Lived Intangible Assets   (359,922)   (332,602)
Total   1,207,842   1,003,301
Indefinite-lived Intangible Assets [Line Items]        
Gross Carrying Amount - Total Intangible Assets   1,708,082   1,518,208
Net Book Value - Total Intangible Assets   1,348,160   1,185,606
Acquired IPR&D assets [Member]        
Indefinite-lived Intangible Assets [Line Items]        
In-process research and development   140,318 $ 182,305  
Increase (decrease) in indefinite-lived intangible assets $ (48,400)      
Sigma-Tau Milestone Payment [Member]        
Indefinite-lived Intangible Assets [Line Items]        
Increase (decrease) in indefinite-lived intangible assets   $ 150,000    
Acquired developed technologies [Member]        
Finite-Lived Intangible Assets [Line Items]        
Remaining Weighted- Average Useful Life (In years)   12 years 1 month    
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 1,552,761   1,321,324
Accumulated Amortization - Finite-Lived Intangible Assets   (350,397)   (324,044)
Total   $ 1,202,364   997,280
Increase in finite-lived intangible assets $ 48,400      
Acquired developed technologies [Member] | Defitelio [Member]        
Finite-Lived Intangible Assets [Line Items]        
Remaining Weighted- Average Useful Life (In years)   14 years    
Manufacturing contracts [Member]        
Finite-Lived Intangible Assets [Line Items]        
Remaining Weighted- Average Useful Life (In years)   1 year 10 months    
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 12,111   11,697
Accumulated Amortization - Finite-Lived Intangible Assets   (6,633)   (5,676)
Total   $ 5,478   6,021
Trademarks [Member]        
Finite-Lived Intangible Assets [Line Items]        
Remaining Weighted- Average Useful Life (In years)   0 years    
Gross Carrying Amount - Finite-Lived Intangible Assets   $ 2,892   2,882
Accumulated Amortization - Finite-Lived Intangible Assets   (2,892)   (2,882)
Total   $ 0   $ 0