Share-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2016

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Share-based compensation expense related to share options, RSUs and grants under our ESPP was as follows (in thousands):



	Three Months Ended March 31,
	2016			2015
Selling, general and administrative	$	20,204		$	16,639
Research and development	3,290			3,485
Cost of product sales	689			695
Total share-based compensation expense, pre-tax	24,183			20,819
Tax benefit from share-based compensation expense	(6,963		)	(6,154		)
Total share-based compensation expense, net of tax	$	17,220		$	14,665

Weighted-Average Assumptions Used in Black-Scholes Option Pricing Model which was Used to Estimate Grant Date Fair Value per Share

The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted:



	Three Months Ended March 31,
	2016			2015
Shares underlying options granted (in thousands)	1,009			880
Grant date fair value	$	40.17		$	57.49
Black-Scholes option pricing model assumption information:
Volatility	39		%	39		%
Expected term (years)	4.2			4.2
Range of risk-free rates	1.0-1.5%			1.1-1.3%
Expected dividend yield	—		%	—		%

Schedule of Restricted Stock Unit activity

The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:



	Three Months Ended March 31,
	2016		2015
RSUs granted (in thousands)	400		338
Grant date fair value	$	123.46	$	174.56