Share-Based Compensation - Share-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 23,114	$ 18,251	$ 67,233	$ 50,618
Tax benefit from share-based compensation expense	(6,658)	(5,469)	(19,722)	(15,171)
Total share-based compensation expense, net of tax	16,456	12,782	47,511	35,447
Selling, general and administrative [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	19,542	14,834	54,843	40,051
Research and development [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	2,786	3,177	10,137	8,862
Cost of product sales [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 786	$ 240	$ 2,253	$ 1,705