Shareholders' Equity - Shareholders Equity (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014	Dec. 31, 2014
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Shareholders equity, beginning of period			$ 1,371,208	$ 1,295,534
Noncontrolling interests from the Gentium Acquisition				136,578
Acquisition of noncontrolling interests			(60)	(136,950)
Issuance of 1.875% exchangeable senior notes due 2021				126,862
Issuance of ordinary shares in conjunction with employee equity incentive and purchase plans and warrant exercises			34,025	48,452
Employee withholding taxes related to share-based awards			(25,402)	(17,306)
Share-based compensation			67,729	50,919
Tax benefit from employee share options			(320)	4,075
Shares repurchased			(21,302)	(29,973)
Other comprehensive income (loss)			(109,174)	(113,293)
Net income (loss)	$ 87,960	$ 25,768	246,773	(24,285)
Shareholders equity, end of period	$ 1,563,477	$ 1,340,613	$ 1,563,477	$ 1,340,613
Convertible Debt [Member]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Interest rate	1.875%	1.875%	1.875%	1.875%	1.875%
Parent [Member]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Shareholders equity, beginning of period			$ 1,371,144	$ 1,295,534
Noncontrolling interests from the Gentium Acquisition				0
Acquisition of noncontrolling interests			(5)	(1,529)
Issuance of 1.875% exchangeable senior notes due 2021				126,862
Issuance of ordinary shares in conjunction with employee equity incentive and purchase plans and warrant exercises			34,025	48,452
Employee withholding taxes related to share-based awards			(25,402)	(17,306)
Share-based compensation			67,729	50,919
Tax benefit from employee share options			(320)	4,075
Shares repurchased			(21,302)	(29,973)
Other comprehensive income (loss)			(109,180)	(113,286)
Net income (loss)			246,774	(23,225)
Shareholders equity, end of period	$ 1,563,463	$ 1,340,523	1,563,463	1,340,523
Noncontrolling Interest [Member]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Shareholders equity, beginning of period			64	0
Noncontrolling interests from the Gentium Acquisition				136,578
Acquisition of noncontrolling interests			(55)	(135,421)
Other comprehensive income (loss)			6	(7)
Net income (loss)			(1)	(1,060)
Shareholders equity, end of period	$ 14	$ 90	$ 14	$ 90