Share-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2015

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Share-based compensation expense related to share options, RSUs and grants under our ESPP was as follows (in thousands):



	Three Months Ended September 30,						Nine Months Ended September 30,
	2015			2014			2015			2014
Selling, general and administrative	$	19,542		$	14,834		$	54,843		$	40,051
Research and development	2,786			3,177			10,137			8,862
Cost of product sales	786			240			2,253			1,705
Total share-based compensation expense, pre-tax	23,114			18,251			67,233			50,618
Tax benefit from share-based compensation expense	(6,658		)	(5,469		)	(19,722		)	(15,171		)
Total share-based compensation expense, net of tax	$	16,456		$	12,782		$	47,511		$	35,447

Weighted-Average Assumptions Used in Black-Scholes Option Pricing Model which was Used to Estimate Grant Date Fair Value per Share

The table below shows the number of shares underlying options granted to purchase our ordinary shares, the weighted-average assumptions used in the Black-Scholes option pricing model and the resulting weighted-average grant date fair value of share options granted:



	Three Months Ended September 30,						Nine Months Ended September 30,
	2015			2014			2015			2014
Shares underlying options granted (in thousands)	106			135			1,056			942
Grant date fair value	$	60.34		$	51.73		$	57.85		$	60.40
Black-Scholes option pricing model assumption information:
Volatility	40		%	42		%	39		%	45		%
Expected term (years)	4.2			4.3			4.2			4.3
Range of risk-free rates	1.3-1.4%			1.3-1.4%			1.1-1.4%			1.1-1.4%
Expected dividend yield	—		%	—		%	—		%	—		%

Schedule of Restricted Stock Unit activity

The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of RSUs granted:



	Three Months Ended September 30,				Nine Months Ended September 30,
	2015		2014		2015		2014
RSUs granted (in thousands)	40		68		406		459
Grant date fair value	$	179.10	$	145.58	$	175.22	$	160.00