EXHIBIT 12.1

JAZZ PHARMACEUTICALS, INC.

RATIO OF EARNINGS TO FIXED CHARGES

	Year Ended December 31,
	2009	2008	2007	2006	2005
Ratio of earnings to fixed charges (1)	N/A	N/A	N/A	N/A	N/A

(1) Our earnings were insufficient to cover fixed charges by $6.8 million, $184.3 million, $138.8 million, $59.4 million and $85.2 million for the years ended December 31, 2009, 2008, 2007, 2006 and 2005, respectively.

COMPUTATION OF RATIOS OF EARNINGS TO FIXED CHARGES

(In thousands)

	Year Ended December 31,
	2009			2008			2007			2006			2005
EARNINGS:
Loss before income taxes	$	(6,836	)	$	(184,339	)	$	(138,826	)	$	(59,391	)	$	(85,156	)
Plus: fixed charges (see below)		23,481			21,037			14,150			14,458			7,361
Total income (loss) to cover fixed charges		16,645			(163,302	)		(124,676	)		(44,933	)		(77,795	)
FIXED CHARGES:
Interest expense		20,249			17,535			12,256			12,757			6,422
Amortization of capitalized expenses and accretion of debt discount related to indebtedness		2,547			2,207			1,391			1,372			707
Estimated interest portion of rental expense		685			1,295			503			329			232
Total fixed charges(1)		23,481			21,037			14,150			14,458			7,361
DEFICIENCY OF EARNINGS TO COVER FIXED CHARGES	$	(6,836	)	$	(184,339	)	$	(138,826	)	$	(59,391	)	$	(85,156	)

(1) For purposes of computing the ratio of earnings to fixed charges, fixed charges consist of interest expense on long and short term debt, amortization of deferred financing costs, accretion of a debt discount, interest imputed related to a government settlement obligation, interest related to a development financing obligation and a portion of rental expense deemed to be representative of interest.