EXHIBIT 12.1

JAZZ PHARMACEUTICALS, INC.

COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES

(In thousands)

	Three Months Ended March 31, 2008			Year Ended December 31,												Period from March 20, 2003 (Inception) to December 31, 2003
				2007			2006			2005			2004
EARNINGS:
Loss before income taxes		(46,710	)		(138,826	)		(59,391	)		(85,156	)		(24,804	)		(2,528	)
Plus: fixed charges (see below)		4,082			14,150			14,458			7,361			109			34
Less: capitalized interest		—			—			—			—			—			—
Total loss to cover fixed charges		(42,628	)		(124,676	)		(44,933	)		(77,795	)		(24,695	)		(2,494	)
FIXED CHARGES:
Interest expense		3,616			12,151			12,000			6,200			—			—
Amortization of capitalized expenses and accretion of debt discount related to indebtedness		171			1,496			2,129			929			—			—
Estimated interest portion of rental expense		295			503			329			232			109			34
Total Fixed Charges (1)		4,082			14,150			14,458			7,361			109			34
DEFICIENCY OF EARNINGS TO COVER FIXED CHARGES	$	(46,710	)	$	(138,826	)	$	(59,391	)	$	(85,156	)	$	(24,804	)	$	(2,528	)

(1) For purposes of computing the ratio of earnings to fixed charges, fixed charges consist of interest expense on long and short-term debt, amortization of deferred financing costs, accretion of a debt discount, interest imputed related to a government settlement obligation and a portion of rental expense deemed to be representative of interest.