X0508 4 2025-11-10 0001347858 22nd Century Group, Inc. XXII 0001231076 SALHANY LUCILLE S C/O 22ND CENTURY GROUP, INC. 321 FARMINGTON RD. MOCKSVILLE NC 24028 true false Common Stock 2025-11-10 4 A 0 11006 0 A 11114 D Non-Qualified Stock Option 1.27 2025-11-10 4 A 0 33020 0 A 2035-11-10 Common Stock 33020 33020 D Non-Qualified Stock Option 46.23 2035-03-10 Common Stock 322 322 D The restricted stock units vest 1/3 per year on November 10, 2026, 2027 and 2028, subject to continued service with the Company. The amount shown reflects the number of shares held following the reported transaction, as adjusted for a 1-for-23 stock split effectuated by the issuer on June 20, 2025. Options vest 1/3 per year on the anniversary of the date of grant, subject to continued service with the Company. /s/ Lucille S. Salhany by John Wolfel, as Attorney-in-fact 2025-11-13