X0303 4 2010-01-23 0001116463 ORASURE TECHNOLOGIES INC OSUR 0001230729 GOLDSTEIN JACK 220 EAST FIRST STREET BETHLEHEM PA 18015 1 0 0 0 Common Stock 2010-01-23 2010-01-25 4 F 0 4500 5.19 D 10500 D Common Stock 2010-01-25 4 A 0 15000 A 25500 D Withholding of shares to pay the tax liability associated with vesting of restricted shares. Grant of restricted shares under the OraSure Technologies, Inc. 2000 Stock Award Plan, cliff vesting on January 25, 2011. Vesting shall cease immediately if the named individual voluntarily ceases to serve as a member of the Board of Directors. Mark L. Kuna, as Attorney-in-Fact for Jack Goldstein, (Power of Attorney previously filed). 2010-01-26