X0306 4 2012-07-13 0 0001158223 AFFYMAX INC AFFY 0001230721 CROSS HERB C/O AFFYMAX, INC. 4001 MIRANDA AVE. PALO ALTO CA 94304 0 1 0 0 Chief Financial Officer Common Stock 2012-07-13 4 M 0 15000 5.10 A 25000 D Common Stock 2012-07-13 4 S 0 15000 15.50 D 10000 D Common Stock 2012-07-17 4 M 0 10000 6.23 A 20000 D Common Stock 2012-07-17 4 S 0 10000 17.00 D 10000 D Stock Option (Right to Buy) 5.10 2012-07-13 4 M 0 15000 0.00 D 2020-11-14 Common Stock 15000 45000 D Stock Option (Right to Buy) 6.23 2012-07-17 4 M 0 10000 0.00 D 2021-03-03 Common Stock 10000 40000 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. 1/4th of the shares vest one year after the vesting commencement date; the balance of the shares vest in a series of thirty-six (36) successive equal monthly installments measured from the first anniversary of the vesting commencement date. The option vests on a monthly basis in equal installments during the 48 month period beginning on March 4, 2011. /s/ Grace U. Shin, Attorney-in-fact 2012-07-17