X0201 42003-10-150 0001040416 INSPIRE PHARMACEUTICALS INC ISPH 0001230708 STAAB THOMAS R II C/O INSPIRE PHARMACEUTICALS, INC. 4222 EMPEROR BLVD. / SUITE 200 DURHAM NC 27703 0100Chief Financial OfficerNon-Statutory Stock Option (right to buy)20.302003-10-154A0100000.0A2013-10-15Common Stock1000010000DExercisable as to one quarter of such shares on 10/15/2004 and 2.0833% of such shares per month thereafter until fully vested./s/ Thomas R. Staab, II2003-10-17