X0306 4 2019-05-16 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001230708 STAAB THOMAS R II 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 Senior Vice President and CFO Common Stock 2019-05-16 4 M 0 4750 1.42 A 134926 D Common Stock 2019-05-16 4 S 0 7250 7.72 D 127676 D Common Stock 2019-05-17 4 S 0 2500 7.45 D 125176 D Emp. Stock Option (Right to Buy) 1.42 2019-05-16 4 M 0 4750 0 D 2014-01-01 2023-01-01 Common Stock 4750 61000 D The transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 7, 2019. The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $7.55 to $8.03. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $7.41 to $7.45. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. /s/ Alane P. Barnes, by power of attorney 2019-05-20