X0609 4 2026-10-23 0001228627 Opus Genetics, Inc. IRD 0001145914 SCHACHLE JOSEPH K false C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27713 false true false false Chief Operating Officer false Common Stock 2026-10-23 4 S false 4767 3.565 D 286673 D The shares reported on this line were sold automatically on behalf of the Reporting Person, as required by the Issuer to satisfy tax withholding obligations that arose in connection with the vesting and settlement of restricted stock units. This transaction does not represent a discretionary trade by the Reporting Person. /s/ Amy Rabourn, by Power of Attorney 2026-10-27