X0609 4 2026-10-23 0001228627 Opus Genetics, Inc. IRD 0001999390 Magrath George false C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27713 true true false false Chief Executive Officer false Common Stock 2026-10-23 4 S false 9591 3.585 D 2038894 D The shares reported on this line were sold automatically on behalf of the Reporting Person, as required by the Issuer to satisfy tax withholding obligations that arose in connection with the vesting and settlement of restricted stock units. This transaction does not represent a discretionary trade by the Reporting Person. /s/ Amy Rabourn, by Power of Attorney 2026-10-27