X0609 4 2026-09-09 0001228627 Opus Genetics, Inc. IRD 0001999390 Magrath George false C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27713 true true Chief Executive Officer false Common Stock 2026-09-09 4 M 0 392157 1.15 A 2124026 D Common Stock 2026-09-09 4 F 0 75541 5.97 D 2048485 D Warrant (right to buy) 1.15 2026-09-09 4 M 0 392157 0 D 2030-03-25 Common Stock 392157 0 D The Reporting Person paid the exercise price of the Warrant on a cashless basis. The Issuer withheld 75,541 shares, calculated in accordance with the terms of the Warrant, to pay the exercise price and issued the remaining 316,616 shares to the Reporting Person. The Warrant was immediately exercisable upon its acquisition on March 24, 2025, subject to the Issuer's right to call the Warrant at any time beginning 30 days following the release of the Issuer's OPGx-BEST1 DUO-1001 Cohort 1 data upon achievement of (i) a volume weighted average price of the Issuer's Common Stock for 30 consecutive trading days of over $1.725 per share and (ii) the trading average daily volume for such 30 day period exceeding $150,000 per trading day. /s/ Amy Rabourn, by Power of Attorney 2026-09-11