X0306 4 2023-01-10 0001228627 Ocuphire Pharma, Inc. OCUP 0001830354 Hoffmann Bernhard C/O OCUPHIRE PHARMA, INC. 37000 GRAND RIVER AVE, SUITE 120 FARMINGTON HILLS MI 48335 true SVP of Corp. Dev. & Ops & Sec. Common Stock 2023-01-10 4 A 0 46608 0 A 146728 D Employee Stock Option (right to buy) 3.5 2023-01-10 4 A 0 69912 0 A 2033-01-09 Common Stock 69912 69912 D Represents a grant of restricted stock units which vest in four equal installments on the first, second, third and fourth anniversary of the grant date of January 10, 2023. The option will vest with respect to 17,478 shares on January 10, 2024, with the balance vesting quarterly in twelve equal installments thereafter. /s/ Emily J. Johns, by Power of Attorney 2023-01-12