X0609 4 2026-03-16 0001228627 Opus Genetics, Inc. IRD 0001832343 Zaremba Rabourn Amy C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27713 false true false false Head of Fin. Quality Assurance false Common Stock 2026-03-16 4 S false 2816 5.245 D 190312 D The shares reported on this line were sold automatically on behalf of the Reporting Person, as required by the Company to satisfy tax withholding obligations that arose in connection with a vesting and settlement event from a restricted stock units award. This transaction does not represent a discretionary trade by the Reporting Person. /s/ Amy Rabourn 2026-03-18