X0508 4 2025-03-24 0001228627 Opus Genetics, Inc. IRD 0001999390 Magrath George C/O OPUS GENETICS, INC. 8 DAVIS DRIVE, SUITE 220 DURHAM NC 27709 true true Chief Executive Officer false Common Stock 2025-03-24 4 A 0 392157 A 1322004 D Warrants (right to buy) 1.15 2025-03-24 4 A 0 392157 A 2030-03-24 Common Stock 392157 392157 D Each share of common stock was purchased together with a warrant to purchase one share of common stock in a transaction that is exempt from Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-3(d) thereunder. The combined purchase price of each pair of common stock and warrant was $1.275. These warrants are immediately exercisable and may be called by the Issuer at any time starting with 30 days following the release of the Issuer's OPGx-BEST1 DUO-1001 Cohort 1 data upon achievement of (i) a volume weighted average price of the Issuer's common stock for 30 consecutive trading days of over $1.725 per share and (ii) the trading average daily volume for such 30 day period exceeding $150,000 per trading day. /s/ Sharon Goldbach, by Power of Attorney 2025-03-26