X0508 4 2024-11-15 0001228627 Opus Genetics, Inc. IRD 0001999390 Magrath George C/O OPUS GENETICS, INC. 37000 GRAND RIVER AVE, SUITE 120 FARMINGTON HILLS MI 48335 true Chief Executive Officer false Common Stock 2024-11-15 4 P 0 90294 1.0102 A 483244 D Common Stock 2024-11-18 4 P 0 9706 1.0244 A 492950 D The price in column 4 represents the weighted average price. The shares were purchased in multiple transactions at prices ranging from $0.975 to $1.05, inclusive. The Reporting Person undertakes to provide the issuer, any securityholder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. The price in column 4 represents the weighted average price. The shares were purchased in multiple transactions at prices ranging from $1.005 to $1.06, inclusive. The Reporting Person undertakes to provide the issuer, any securityholder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Amy Rabourn, by Power of Attorney 2024-11-19