<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-07-19</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001227073</issuerCik>
        <issuerName>WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND</issuerName>
        <issuerTradingSymbol>ERC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001496804</rptOwnerCik>
            <rptOwnerName>Shiver Mai S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>WELLS CAPITAL MANAGEMENT</rptOwnerStreet1>
            <rptOwnerStreet2>525 MARKET STREET, 10TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>CCO of sub-advisor</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>/s/Catherine F. Kennedy by power of attorney</signatureName>
        <signatureDate>2010-07-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
