Condensed Consolidated Statements of Stockholders' Equity - USD ($)	Total	Common stock	Additional paid-in capital	Accumulated other comprehensive loss	Accumulated deficit
Balance at Dec. 31, 2020	$ 71,326,500	$ 45,025	$ 454,296,536	$ (88,219)	$ (382,926,842)
Balance, shares at Dec. 31, 2020		45,024,560
Share-based compensation	1,139,636		1,139,636
Issuance of common stock for option exercises	212,175	$ 86	212,089
Issuance of common stock for option exercises, shares		86,250
Issuance of shares under an employee stock purchase plan (ESPP)	6,110	$ 2	6,108
Issuance of shares under an employee stock purchase plan (ESPP), shares		1,424
Issuance of common stock in a private placement transaction, net of issuance costs	19,881,648	$ 3,656	19,877,992
Issuance of common stock in a private transaction, net of issuance costs, shares		3,656,307
Net loss	(187,799)				(187,799)
Foreign currency translation adjustments	(6,821)			(6,821)
Balance at Mar. 31, 2021	92,371,449	$ 48,769	475,532,361	(95,040)	(383,114,641)
Balance, shares at Mar. 31, 2021		48,768,541
Balance at Dec. 31, 2021	83,677,084	$ 49,043	476,788,012	(98,877)	(393,061,094)
Balance, shares at Dec. 31, 2021		49,043,246
Share-based compensation	81,053		81,053
Net loss	(3,386,417)				(3,386,417)
Foreign currency translation adjustments	(7,435)			(7,435)
Balance at Mar. 31, 2022	$ 80,364,285	$ 49,043	$ 476,869,065	$ (106,312)	$ (396,447,511)
Balance, shares at Mar. 31, 2022		49,043,246