<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: GATES MELINDA FRENCH -->
          <cik>0001226523</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common stock, par value $0.01 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>10/01/2024</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0000350698</issuerCik>
        <issuerName>AUTONATION, INC.</issuerName>
        <issuerCusip>05329W102</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>200 SW 1ST AVENUE</com:street1>
          <com:city>FORT LAUDERDALE</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33301</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>GATES MELINDA FRENCH</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2808674.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>2808674.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2808674.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.1</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>AUTONATION, INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>200 SW 1ST AVE, FORT LAUDERDALE, FLORIDA 33301</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>GATES MELINDA FRENCH</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>12335 134th Ct NE, Redmond, WA 98052</principalBusinessOfficeOrResidenceAddress>
        <citizenship>United States</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>See Row 9 of the Reporting Person's cover page. Shares beneficially owned includes shares directly owned by a charitable foundation of which the Reporting Person is the sole director.</amountBeneficiallyOwned>
        <classPercent>Percentage beneficial ownership is based on 39,679,183 Shares outstanding as of July 30, 2024, as disclosed in the Issuer's Quarterly Report on Form 10-Q for the period ended June 30, 2024.

7.1</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>See Row 5 of the Reporting Person's cover page.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>See Row 6 of the Reporting Person's cover page.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>See Row 7 of the Reporting Person's cover page.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>See Row 8 of the Reporting Person's cover page.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 99.1: Duly authorized under Power of Attorney by and on behalf of Melinda French Gates.</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>GATES MELINDA FRENCH</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Brooke Anderson</signature>
        <title>Attorney-in-fact</title>
        <date>10/08/2024</date>
      </signatureDetails>
    </signatureInformation>
    <signatureComments>Exhibit 99.1: Duly authorized under Power of Attorney by and on behalf of Melinda French Gates.</signatureComments>
  </formData>

</edgarSubmission>
