EXHIBIT E

                               SECURITY AGREEMENT

      This SECURITY AGREEMENT is made as of February 16, 2006 between the
lenders listed on the signature page hereto (hereinafter, collectively, the
"SECURED PARTIES") and Access Pharmaceuticals, Inc., a Delaware corporation with
its chief executive office located at 2600 Stemmons Freeway, Suite 176, Dallas,
Texas 75207, Attention: President (the "DEBTOR").

                              W I T N E S S E T H:

      WHEREAS, on the date hereof, the Debtor has issued in favor of each of the
Secured Parties, promissory notes (each a "NOTE" and collectively the "NOTES"),
in the aggregate principal amount of Five Million Dollars ($5,000,000); such
Notes have been issued pursuant to the terms of a Convertible Note and Warrant
Purchase Agreement (the "PURCHASE AGREEMENT") of even date herewith between the
Debtor and the Secured Parties; and

      WHEREAS, it is a condition precedent to the Secured Parties' making any
loans under Purchase Agreement and the Notes or otherwise extending credit to
the Debtor that the Debtor execute and deliver to the Lenders this Security
Agreement;

      NOW, THEREFORE, in consideration of the premises and to induce the Secured
Parties to extend the loans to the Debtor pursuant to the Notes, the Debtor
hereby agrees with the Secured Parties as follows:

      1.    DEFINED TERMS.

      (a)   Unless otherwise defined herein, terms, which are defined in the
      Note and used herein, shall have the meanings ascribed to such terms in
      the Note.

      (b)   The following terms which are defined in Article 9 are used herein
      as so defined: Accessions, Accounts, Chattel Paper, Commercial Tort
      Claims, Deposit Accounts, Documents, Equipment, General Intangibles,
      Goods, Instruments, Inventory, Investment Property, Letters of Credit,
      Letter-of-Credit Rights, Payment Intangibles, Proceeds, Promissory Notes,
      Software and Supporting Obligations.

      (c)   The following terms shall have the following meanings:

      "ARTICLE 9" means Article 9 of the Code as in effect from time to time.

      "CODE" means the Uniform Commercial Code as from time to time in effect in
      the State of New York, including, specifically, Article 9.

      "COLLATERAL" shall have the meaning assigned to it in Section 2 of this
      Security Agreement.


                                        1



      "CONTRACTS" means the separate contracts between the Debtor and third
      parties (including without limitation its customers), as the same may from
      time to time be amended, supplemented or otherwise modified, including,
      without limitation, (a) all rights of the Debtor to receive moneys due and
      to become due to it thereunder or in connection therewith, (b) all rights
      of the Debtor to damages arising out of, or for, breach or default in
      respect thereof and (c) all rights of the Debtor to perform and to
      exercise all remedies thereunder; but excluding any contracts, the
      assignment or hypothecation of which, for collateral purposes, would
      result in a default or require, or cause, a forfeiture or permit a
      revocation of material rights under such contract.

      "COPYRIGHTS" means (a) all copyrights of the United States or any other
      country, (b) all copyright registrations filed in the United States or in
      any other country, and (c) all Proceeds thereof.

      "COPYRIGHT LICENSE" means any Contract providing for the grant by Debtor
      of any right to use any Copyright.

      "CUSTOMER CONTRACTS" means Contracts between the Debtor and its customers.

      "ENCUMBRANCE" or "ENCUMBRANCES" means any security interest, mortgage,
      pledge, lien, claim, charge, encumbrance, title retention agreement,
      lessor's interest under a financing lease or any analogous arrangements in
      any of properties or assets of Debtor, intended as, or having the effect
      of, security.

      "EVENT OF DEFAULT" as defined in each Note.

      "GOVERNMENTAL AUTHORITY" means any Federal, state, local or foreign court,
      commission or tribunal, or governmental, administrative or regulatory
      agency, department, authority, instrumentality or other body.

      "MATERIAL ADVERSE EFFECT" means a material adverse effect on the condition
      (financial or otherwise), assets, liabilities, business, results of
      operations or prospects of the Debtor, taken as a whole.

      "OBLIGATIONS" means all principal, interest, fees, charges, collateral
      protection expenses, enforcement costs and other sums (in each case
      whether pre-or-post petition) due or to become due and payable by Debtor
      to any of the Secured Parties under the Notes, this Agreement or the
      Purchase Agreement.

      "PATENTS" means (a) all patents of the United States and all reissues and
      extensions thereof, (b) all applications for patents of the United States
      and all divisions, continuations and continuations-in-part thereof or any
      other country, and (c) all Proceeds thereof.

      "PATENT LICENSE" means any Contract providing for the grant by Debtor of
      any right to manufacture, use or sell any invention covered by a Patent.


                                        2



      "PERMITTED ENCUMBRANCES" means any of the following Encumbrances that
      exist or that the Debtor may create or incur or suffer to be created or
      incurred or to exist : (i) liens to secure taxes, assessments and other
      government charges in respect of obligations not overdue or liens on
      properties to secure claims for labor, material or supplies in respect of
      obligations not overdue; (ii) deposits or pledges made in connection with,
      or to secure payment of, workmen's compensation, unemployment insurance,
      old age pensions or other social security obligations; (iii) liens of
      carriers, warehousemen, mechanics and materialmen, and other like liens on
      properties in existence less than 180 days from the date of creation
      thereof in respect of obligations not overdue; (iv) encumbrances on real
      estate consisting of easements, rights of way, zoning restrictions,
      restrictions on the use of real property and defects and irregularities in
      the title thereto, landlord's or lessor's liens under leases to which the
      Debtor is a party, and other minor liens or encumbrances none of which in
      the opinion of the Debtor interferes materially with the use of the
      property affected in the ordinary conduct of business of the Debtor, which
      defects do not individually or in the aggregate have a Material Adverse
      Effect; (v) purchase money security interests in or purchase money
      mortgages on real or personal property to secure purchase money
      indebtedness, incurred in connection with the acquisition of such
      property, which security interests or mortgages cover only the real or
      personal property so acquired or (vi) security interests in the sale and
      lease back of real and personal property, the aggregate value of which
      does not exceed $500,000 during the term of the Note (such aggregate value
      limitation to include any encumbrances on the assets of any subsidiary of
      the Company pursuant to Section 5(e)(vi) of the Note).

      "PERSON" means an individual, partnership, corporation, limited liability
      company, business trust, joint stock company, trust, unincorporated
      association, joint venture or other entity of whatever nature, whether
      public or private.

      "REQUIREMENT OF LAW" means any requirement of law, rule, regulation or
      guideline of any Governmental Authority.

      "SECURITY AGREEMENT" means this Security Agreement, as amended,
      supplemented, restated or otherwise modified from time to time.

      "SOFTWARE LICENSE" means any agreement, written or oral, providing for the
      grant by Debtor of any right to use any Software.

      "SOURCE CODE" means all source code and all updates, releases and/or new
      versions of the Software.

      "TRADEMARKS" means (a) all trademarks, trade names, corporate names,
      company names, business names, fictitious business names, trade styles,
      service marks, logos and other source or business identifiers and the
      goodwill associated therewith, now existing or hereafter adopted or
      acquired, all registrations and recordings thereof, and all applications
      in connection therewith, whether registered in the United States Patent
      and Trademark Office or in any similar office or agency of the United
      States, any State thereof or any


                                        3



      other country or any political subdivision thereof or otherwise, (b) all
      renewals thereof, and (c) all Proceeds thereof, including the goodwill of
      the business connected with the use of and symbolized by the Trademarks.

      "TRADEMARK LICENSE" means any Contract providing for the grant by Debtor
      of any right to use any Trademark.

      2.    GRANT OF SECURITY INTEREST.

      (a)   As collateral security for the prompt and complete payment and
      performance when due of the Obligations, the Debtor hereby grants to each
      of the Secured Parties a security interest in all properties, assets and
      rights of the Debtor now owned or at any time hereafter acquired by the
      Debtor or in which the Debtor now has or at any time in the future may
      acquire any right, title or interest, wherever located or situated and
      however defined or classified under Article 9, including, without
      limitation, all of the property described in clause (b) below
      (collectively, the "COLLATERAL").

      (b)   Without limitation of the foregoing, the Collateral includes all of
      Debtor's right, title and interest in the following at all times:

                     (i)      all Accounts;

                    (ii)      all Chattel Paper;

                   (iii)      all Commercial Tort Claims;

                    (iv)      all Contracts;

                     (v)      all Copyrights;

                    (vi)      all Copyright Licenses;

                   (vii)      all Deposit Accounts;

                  (viii)      all Documents;

                    (ix)      all Equipment;

                     (x)      all General Intangibles;

                    (xi)      all Goods;

                   (xii)      all Instruments;

                  (xiii)      all Inventory;


                                        4



                   (xiv)      all Investment Property;

                    (xv)      all Letter-of-Credit Rights;

                   (xvi)      all Letters of Credit;

                  (xvii)      all Patents;

                 (xviii)      all Patent Licenses;

                   (xix)      all Payment Intangibles;

                    (xx)      all Promissory Notes;

                   (xxi)      all Software (including, without limitation, any
                              Source Code thereto, all Software Licenses and any
                              Patents or Copyrights associated therewith);

                  (xxii)      all Supporting Obligations;

                 (xxiii)      all Trademarks;

                  (xxiv)      all Trademark Licenses;

                   (xxv)      all Proceeds, all Accessions and additions thereto
                              and all substitutions and replacements therefor
                              and products of any and all of the foregoing.

      3.    RIGHTS OF SECURED PARTIES; LIMITATIONS ON SECURED PARTIES'
OBLIGATIONS.

      (a)   Debtor Remains Liable under Accounts and Contracts. Anything herein
      to the contrary notwithstanding, the Debtor shall remain liable under each
      of the Accounts and Contracts to observe and perform all the conditions
      and obligations to be observed and performed by it thereunder, all in
      accordance with the terms of any agreement giving rise to each such
      Account and in accordance with and pursuant to the terms and provisions of
      each such Contract. None of the Secured Parties shall have any obligation
      or liability under any Account (or any agreement giving rise thereto) or
      under any Contract by reason of or arising out of this Security Agreement
      or the receipt by any Secured Party of any payment relating to such
      Account or Contract pursuant hereto, nor shall any Secured Party be
      obligated in any manner to perform any of the obligations of the Debtor
      under or pursuant to any Account (or any agreement giving rise thereto) or
      under or pursuant to any Contract, to make any payment, to make any
      inquiry as to the nature or the sufficiency of any payment received by it
      or as to the sufficiency of any performance by any party under any Account
      (or any agreement giving rise thereto) or under any Contract, to present
      or file any claim, to take any action to enforce any performance or to


                                        5



      collect the payment of any amounts which may have been assigned to it or
      to which it may be entitled at any time or times.

      (b)   Notice to Account Debtors and Contracting Parties. At any time after
      the occurrence of an Event of Default, upon the request of any Secured
      Party, the Debtor shall notify account debtors on the Accounts and parties
      to the Contracts that the Accounts and the Contracts have been assigned to
      the Secured Parties, and that payments in respect thereof shall be made
      directly to them. Upon the occurrence of an Event of Default, the Secured
      Parties, may in its own name or in the name of others communicate with
      account debtors on the Accounts and parties to the Contracts to verify
      with them to the Secured Parties' reasonable satisfaction the existence,
      amount and terms of any Accounts or Contracts.

      4.    REPRESENTATIONS AND WARRANTIES. The Debtor hereby represents and
warrants to the Secured Parties that (a) it is a corporation duly organized,
validly existing and in good standing under the laws of the State of Delaware,
(b) it has the corporate power and authority to own or hold under lease the
Collateral, to transact the business it transacts and proposes to transact, to
execute and deliver this Security Agreement and to perform the provisions
hereof, (c) this Security Agreement has been duly authorized by all necessary
corporate action on the part of the Debtor and constitutes a legal, valid and
binding obligation of the Debtor enforceable against the Debtor in accordance
with its terms, except as such enforceability may be limited by (i) applicable
bankruptcy, insolvency, reorganization, fraudulent conveyance, moratorium or
other similar laws affecting the enforcement of creditors' rights generally and
(ii) general principles of equity (regardless of whether such enforceability is
considered in a proceeding in equity or at law), (d) the execution, delivery and
performance by the Debtor of this Security Agreement will not (i) to the
knowledge of the Debtor, contravene, result in any breach of, or constitute a
default under, or result in the creation of any lien (other than those provided
for in this Security Agreement) in respect of any property of the Debtor under,
any indenture, mortgage, deed of trust, loan, purchase or credit agreement,
lease, the Debtor's articles of incorporation or bylaws, or any other material
agreement or instrument to which the Debtor is a party or by which the Debtor or
any of its properties may be bound or affected; (ii) conflict with or result in
a breach of any of the terms, conditions or provisions of any order, judgment,
decree, or ruling of any court, arbitrator or Governmental Authority applicable
to the Debtor, or (iii) to the knowledge of the Debtor, violate any provision of
any statute or other rule or regulation of any Governmental Authority applicable
to the Debtor, (e) except for the Encumbrances granted pursuant to this Security
Agreement and Permitted Encumbrances, the Debtor owns each item of the
Collateral free and clear of any and all Encumbrances or claims of others, and
(f) except in connection with Permitted Encumbrances, no security agreement,
financing statement or other public notice with respect to all or any part of
the Collateral is on file or of record in any public office, except such as may
have been filed in favor of the Secured Parties.

      5.    COVENANTS. The Debtor covenants and agrees with the Secured Parties
that, from and after the date of this Security Agreement until the Obligations
are paid in full:

      (a)   Further Documentation; Pledge of Instruments and Chattel Paper. Upon
      the written request of the Secured Parties, and at the sole expense of the
      Debtor, the Debtor


                                        6



      will promptly and duly execute and deliver such further instruments and
      documents and take such further action as the Secured Parties may
      reasonably request for the purpose of obtaining or preserving the full
      benefits of this Security Agreement and of the rights and powers herein
      granted, including, without limitation, the filing of any financing or
      continuation statements under the Uniform Commercial Code in effect in any
      jurisdiction with respect to the Encumbrances created hereby. The Debtor
      also hereby authorizes the Secured Parties to file any such financing or
      continuation statement. A carbon, photographic or other reproduction of
      this Security Agreement shall be sufficient as a financing statement for
      filing in any jurisdiction. If any amount payable under or in connection
      with any of the Collateral shall be or become evidenced by any Instrument
      or Chattel Paper, such Instrument or Chattel Paper shall be delivered to
      the Secured Parties (if requested by the Secured Parties), duly endorsed
      in a manner satisfactory to the Secured Parties to be held as Collateral
      pursuant to this Security Agreement.

      (b)   Indemnification. Following the occurrence of any Event of Default,
      in any suit, proceeding or action brought by any Secured Party under any
      Account or Contract for any sum owing thereunder, or to enforce any
      provisions of any Account or Contract, the Debtor will save, indemnify and
      keep the Secured Parties harmless from and against all expense, loss or
      damage suffered by reason of any defense, setoff, counterclaim, recoupment
      or reduction or liability whatsoever of the account debtor or obligor
      thereunder, arising out of a breach by the Debtor of any obligation
      thereunder or arising out of any other agreement, indebtedness or
      liability at any time owing to or in favor of such account debtor or
      obligor or its successors from the Debtor.

      (c)   Maintenance of Records. The Debtor will keep and maintain at its own
      cost and expense satisfactory and complete records of the Collateral,
      including, without limitation, a record of all payments received and all
      credits granted with respect to the Accounts. The Debtor will mark its
      books and records pertaining to the Collateral to evidence this Security
      Agreement and the security interests granted hereby. The Secured Parties
      shall have a security interest in all of the Debtor's books and records
      pertaining to the Collateral, and the Debtor shall make any such books and
      records available to the Secured Parties or to their representatives
      during normal business hours for their review at the request of the
      Secured Parties upon reasonable prior notice.

      (d)   Right of Inspection. The Secured Parties shall at all times but no
      more than once every six (6) months and upon reasonable prior notice have
      full and free access during normal business hours to all the books,
      correspondence and records of the Debtor, and the Secured Parties or their
      respective representatives may examine the same, take extracts therefrom
      and make photocopies thereof, and the Debtor agrees to render to the
      Secured Parties, at the Debtor's cost and expense, such clerical and other
      assistance as may be reasonably requested with regard thereto. The Secured
      Parties and their representatives shall at any reasonable time, but no
      more than once every six (6) months, and upon reasonable prior notice also
      have the right to enter into and upon any premises where any of the
      Inventory or Equipment is located for the purpose of inspecting the same,
      observing its use or otherwise protecting its interests-therein.


                                        7



      (e)   Compliance with Laws, etc. The Debtor will comply in all material
      respects with all Requirements of Law applicable to the Collateral or any
      part thereof or to the operation of the Debtor's business; provided,
      however, that the Debtor may contest any Requirement of Law in any
      reasonable manner which shall not, in the opinion of the Secured Parties,
      adversely affect the Secured Parties' rights or the priority of its
      Encumbrances on the Collateral.

      (f)   Compliance with Terms of Contracts, etc. The Debtor will perform and
      comply in all material respects with all its obligations under the
      Contracts and all its other contractual obligations relating to the
      Collateral except where such nonperformance and noncompliance could not
      reasonably be expected to have a Material Adverse Effect.

      (g)   Payment of Obligations. The Debtor will pay promptly when due all
      taxes, assessments and governmental charges or levies imposed upon the
      Collateral or in respect of its income or profits therefrom, as well as
      all claims of any kind (including, without limitation, claims for labor,
      materials and supplies) against or with respect to the Collateral, except
      that no such charge need be paid if (i) the validity thereof is being
      contested in good faith by appropriate proceedings, (ii) such proceedings
      do not involve any material danger of the sale, forfeiture or loss of any
      of the Collateral or any interest therein and (iii) such charge is
      adequately reserved against on the Debtor's books in accordance with
      generally accepted accounting principles.

      (h)   Limitation on Encumbrances on Collateral. The Debtor will not
      create, incur or permit to exist, will defend the Collateral against, and
      will take such other action as is necessary to remove, any Encumbrance or
      claim on or to the Collateral, other than the Encumbrances created hereby
      or Permitted Encumbrances, and will defend the right, title and interest
      of the Secured Parties in and to any of the Collateral against other
      claims and demands of all Persons whomsoever.

      (i)   Limitations on Dispositions of Collateral. The Debtor will not sell,
      transfer, lease or otherwise dispose of any of the Collateral, or attempt,
      offer or contract to do so except for (x) sales of Inventory in the
      ordinary course of its business and (y) so long as no Event of Default has
      occurred, the disposition in the ordinary course of business of property
      not material to the conduct of its business.

      (j)   Limitations on Modifications, Waivers, Extensions of Contracts and
      Agreements Giving Rise to Accounts. The Debtor will not (i) amend, modify,
      terminate or waive any provision of any Contract or any agreement giving
      rise to an Account in any manner which could reasonably be expected to
      materially adversely affect the value of all Contracts and Accounts as
      Collateral when examined in the aggregate or (ii) fail to exercise
      promptly and diligently each and every material right which it may have
      under each Contract and each agreement giving rise to an Account where
      such failure could reasonably be expected to have a Material Adverse
      Effect on the value of all Contracts and Accounts when examined in the
      aggregate.


                                        8



      (k)   Maintenance of Equipment. The Debtor will maintain each item of
      Equipment in good operating condition, ordinary wear and tear and
      immaterial impairments of value and damage by the elements excepted, and
      will provide all maintenance, service and repairs necessary for such
      purpose except where the failure to maintain such Equipment could not
      reasonably be expected to have a Material Adverse Effect.

      (l)   Further Identification of Collateral. The Debtor will furnish to the
      Secured Parties from time to time, but no more than once per year,
      statements and schedules further identifying and describing the Collateral
      and such other reports in connection with the Collateral as the Secured
      Parties may reasonably request, all in reasonable detail.

      (m)   Notices. The Debtor will advise the Secured Parties promptly, in
      reasonable detail, (i) of any Encumbrance (other than Encumbrances created
      hereby or Permitted Encumbrances) on, or claim asserted against, any of
      the Collateral, (ii) of any notice sent by a Secured Party of the
      occurrence of an Event of Default under such Secured Party's Note and
      (iii) of the occurrence of any other event which could reasonably be
      expected to have a Material Adverse Effect on the aggregate value of the
      Collateral or on the Encumbrances created hereunder.

      (o)   Changes in Locations, Name, etc. The Debtor shall provide Secured
      Parties with at least thirty (30) days prior written notice in the event
      of either (i) a change the location of its chief executive office/chief
      place of business or jurisdiction of incorporation or remove its books and
      records from such location, or (ii) change its name, identity or corporate
      structure to such an extent that any financing statement filed by the
      Secured Parties in connection with this Security Agreement would become
      seriously misleading.

      (p)   Patents, Copyrights, Software, Trademarks and General Intangibles.

            (i)     Whenever Debtor shall file an application for the
            registration of any Patent, Software or Trademark with the United
            States Patent and Trademark Office or any Copyright or Software with
            the United States Copyright Office or any similar office or agency
            in any other country or any political subdivision thereof, Debtor
            shall report such filing to the Secured Parties within five (5)
            business days after the last day of the fiscal quarter in which such
            filing occurs.

            (ii)    The Debtor shall execute and deliver any and all agreements,
            instruments, documents, and papers as the Secured Parties may
            reasonably request to evidence the Secured Parties' security
            interest in any Patent, Copyright, Software, General Intangible or
            Trademark and the goodwill of Debtor relating thereto or represented
            thereby, and Debtor hereby constitutes the each of the Secured
            Parties as its attorney-in-fact to execute and file all such
            writings for the foregoing purposes, all acts of such attorney being
            hereby ratified and confirmed; such power being coupled with an
            interest is irrevocable until the Obligations are paid in full.


                                        9



            (iii)   The Debtor will take all reasonable and necessary steps,
            including, without limitation, in any proceeding before the United
            States Patent and Trademark Office, or any similar office or agency
            in any other country or any political subdivision thereof, to
            maintain and pursue each application (and to obtain the relevant
            registration) and to maintain each registration of any registered
            Patents, Copyrights, Software, General Intangibles or Trademarks,
            including, without limitation, filing of applications for renewal,
            affidavits of use and affidavits of incontestability.

            (iv)    In the event that any material Patent, Copyright, Software,
            General Intangible or Trademark included in the Collateral is
            infringed, misappropriated or diluted by a third party, Debtor shall
            promptly notify the Secured Parties after it learns thereof and
            shall, unless Debtor shall reasonably determine that such Patent,
            Copyright, Software, General Intangible or Trademark is of
            negligible economic value to Debtor, promptly sue for infringement,
            misappropriation or dilution, to seek injunctive relief where
            appropriate and to recover any and all damages for such
            infringement, misappropriation or dilution, or take such other
            actions as Debtor shall reasonably deem appropriate under the
            circumstances to protect such Patent, Copyright, Software, General
            Intangible or Trademark.

      (q)   Commercial Tort Claims. The Debtor shall promptly notify the Secured
      Parties in writing upon incurring or otherwise obtaining a Commercial Tort
      Claim against any third party, and upon request of the Secured Parties,
      promptly enter into an amendment to this Security Agreement and do such
      other acts or things deemed appropriate by the Secured Parties to give the
      Secured Parties a security interest in any such Commercial Tort Claim.

      6.    SECURED PARTIES' APPOINTMENT AS ATTORNEY-IN-FACT.

      (a)   Powers. During the existence of an Event of Default, the Debtor
      hereby irrevocably constitutes and appoints each of the Secured Parties
      with full power of substitution, as its true and lawful attorney-in-fact
      with full irrevocable power and authority in the place and stead of Debtor
      and in the name of Debtor or in its own name, from time to time in the
      Secured Parties' discretion, for the purpose of carrying out the terms of
      this Security Agreement, to take any and all appropriate action and to
      execute any and all documents and instruments which may be necessary or
      desirable to accomplish the purposes of this Security Agreement, and,
      without limiting the generality of the foregoing, Debtor hereby gives each
      of the Secured Parties the power and right, on behalf of Debtor, without
      notice to or assent by Debtor, to do the following: to pay or discharge
      taxes and Encumbrances (other than Permitted Encumbrances) levied or
      placed on the Collateral, to effect any repairs or any insurance called
      for by the terms of this Security Agreement and to pay all or any part of
      the premiums therefor and the costs thereof; and during the existence of
      an Event of Default and only upon written instruction of the Secured
      Parties, (A) to direct any party liable for any payment under any of the
      Collateral to make payment of any and all moneys due or to become due
      thereunder directly to the Secured Parties or as the Secured Parties shall
      direct; (B) to ask or demand for, collect, receive payment of and receipt
      for, any and all moneys, claims and other


                                       10



      amounts due or to become due at any time in respect of or arising out of
      any Collateral; (C) to sign and endorse any invoices, freight or express
      bills, bills of lading, storage or warehouse receipts, drafts against
      debtors, assignments, verifications, notices and other documents in
      connection with any of the Collateral; (D) to commence and prosecute any
      suits, actions or proceedings at law or in equity in any court of
      competent jurisdiction to collect the Collateral or any thereof and to
      enforce any other right in respect of any Collateral; (E) to defend any
      suit, action or proceeding brought against Debtor with respect to any
      Collateral; (F) to settle, compromise or adjust any suit, action or
      proceeding described in clause (E) above and, in connection therewith, to
      give such discharges or releases as the Secured Parties may deem
      appropriate; (G) to assign any Patent, Copyright, Software, General
      Intangible or Trademark (along with the goodwill of the business to which
      any such Trademark pertains), throughout the world for such term or terms,
      on such conditions, and in such manner, as the Secured Parties shall
      determine; and (H) generally, to sell, transfer, pledge and make any
      agreement with respect to or otherwise deal with any of the Collateral as
      fully and completely as though the Secured Parties were the absolute owner
      thereof for all purposes, and to do, at the Secured Parties' option and
      Debtor's expense, at any time, or from time to time, all acts and things
      which the Secured Parties deem necessary to protect, preserve or realize
      upon the Collateral and the Secured Parties' Encumbrances thereon and to
      effect the intent of this Security Agreement, all as fully and effectively
      as Debtor might do. The Debtor hereby ratifies all that said attorneys
      shall lawfully do or cause to be done by virtue hereof. This power of
      attorney is a power coupled with an interest and shall be irrevocable.

      (b)   Other Powers. The Debtor also authorizes the Secured Parties, at any
      time and from time to time, to execute, in connection with the sale
      provided for in Section 9 hereof, any endorsements, assignments or other
      instruments of conveyance or transfer with respect to the Collateral.

      (c)   No Duty on Secured Parties' Part. The powers conferred on the
      Secured Parties hereunder are solely to protect Secured Parties' interests
      in the Collateral and shall not impose any duty upon the Secured Parties
      to exercise any such powers. The Secured Parties shall be accountable only
      for amounts that it actually receives as a result of the exercise of such
      powers, and none of them nor any of their officers, directors, or
      employees shall be responsible to Debtor for any act or failure to act
      hereunder, except for its own gross negligence or willful misconduct.

      7.    PERFORMANCE BY SECURED PARTY OF DEBTOR'S OBLIGATIONS. If Debtor
fails to perform or comply with any of its agreements contained herein and the
Secured Parties shall itself perform or comply, or otherwise cause performance
or compliance, with such agreement, the reasonable expenses of the Secured
Parties incurred in connection with such performance or compliance, together
with interest thereon at a rate per annum equal to 12%, shall be payable by
Debtor to the Secured Parties on demand and shall constitute Obligations secured
hereby.

      8.    PROCEEDS. In addition to the rights of the Secured Parties specified
in Section 3 with respect to payments of Accounts, it is agreed that during the
existence of an Event of


                                       11



Default (a) all Proceeds received by the Debtor consisting of cash, checks and
other near-cash items shall be held by the Debtor in trust for the Secured
Parties, segregated from other funds of the Debtor, and shall, forthwith upon
receipt by the Debtor, be turned over to the Secured Parties in the exact form
received by the Debtor (duly endorsed by the Debtor to the Secured Parties), and
(b) any and all such Proceeds received by the Secured Parties (whether from the
Debtor or otherwise) may, in the sole discretion of the Secured Parties, be held
by the Secured Parties as collateral security for, and/or then or at any time
thereafter may be applied by the Secured Parties, pro ratably against, the
Obligations or in such order as the Secured Parties may elect. Any balance of
such Proceeds remaining after the Obligations shall have been paid in full,
shall be paid over to the Debtor or to whomsoever may be lawfully entitled to
receive the same.

      9.    REMEDIES. Upon the occurrence of an Event of Default, the Required
Secured Parties may exercise, in addition to all other rights and remedies
granted to it in this Security Agreement and in any other instrument or
agreement securing, evidencing or relating to the Obligations, all rights and
remedies of a secured party under the Code. Without limiting the generality of
the foregoing, the Secured Parties, during the existence of an Event of Default
and without further demand of performance or other demand, presentment, protest,
advertisement or notice of any kind (except any notice required by law referred
to below) to or upon Debtor or any other Person (all and each of which demands,
defenses, advertisements and notices are hereby waived), may in such
circumstances forthwith collect, receive, appropriate and realize upon the
Collateral, or any part thereof, and/or may forthwith sell, lease, assign, give
option or options to purchase, or otherwise dispose of and deliver the
Collateral or any part thereof (or contract to do any of the foregoing), in one
or more parcels at public or private sale or sales, at any exchange, broker's
board or office of any of the Secured Parties or elsewhere upon such terms and
conditions as it may deem advisable and at such prices as it may deem best, for
cash or on credit or for future delivery without assumption of any credit risk.
Each purchaser at any such sale shall hold the Collateral sold absolutely free
from any claim or right on the part of the Debtor, and Debtor hereby waives (to
the extent permitted by law) all rights of redemption, stay, or appraisal that
it now has or may at any time in the future have under any rule of law or
statute now existing or hereafter enacted. Each of the Secured Parties shall
have the right upon any such public sale or sales, and, to the extent permitted
by law, upon any such private sale or sales, to purchase the whole or any part
of the Collateral so sold, free of any right or equity of redemption in Debtor,
which right or equity is hereby waived or released, and in connection herewith
to credit bid the Obligations with the proceeds that would otherwise be payable
to such Secured Party. The Secured Parties shall not be obligated to make any
sale of Collateral regardless of notice of sale having been given. The Secured
Parties may adjourn any public or private sale from time to time by announcement
at the time and place fixed therefor, and such sale may, without further notice,
be made at the time and place to which it was so adjourned. To the extent
permitted by law, Debtor hereby waives any claims against the Secured Parties
arising because the price at which any Collateral may have been sold at a
private sale was less than the price that might have been obtained at a public
sale. The Debtor further agrees, at the Secured Parties' request to assemble the
Collateral and make it available to the Secured Parties at places, which the
Secured Parties shall reasonably select, whether at Debtor's premises or
elsewhere. The Secured Parties shall apply the net proceeds of any such
collection, recovery, receipt, appropriation, realization or sale, after
deducting all reasonable costs and expenses of every kind incurred therein or
incidental to the care or safekeeping of any of the Collateral or in any way


                                       12



relating to the Collateral or the rights of the Secured Parties hereunder,
including, without limitation, reasonable attorneys' fees and disbursements, to
the payment in whole or in part of the Obligations, in such order as the Secured
Parties may elect, and only after such application and after the payment by
Secured Parties of any other amount required by any provision of law, including,
without limitation, any provision of the Code, need the Secured Parties account
for the surplus, if any, to Debtor. To the extent permitted by applicable law,
Debtor waives all claims, damages and demands it may acquire against any Secured
Party arising out of the exercise by any Secured Party of any of its rights
hereunder. If any notice of a proposed sale or other disposition of Collateral
shall be required by law, such notice shall be deemed reasonable and proper if
given at least ten (10) days before such sale or other disposition. The Debtor
shall remain liable for any deficiency if the proceeds of any sale or other
disposition of the Collateral are insufficient to pay the obligations and the
fees and disbursements of any attorneys employed by any Secured Party to collect
such deficiency. Debtor hereby agrees that any sale or other disposition of the
Collateral conducted in conformity with reasonable commercial practices of
banks, insurance companies, or other financial institutions in the city and
state where any Secured Party is located in disposing of property similar to the
Collateral shall be deemed to be commercially reasonable.

      10.   LIMITATION ON DUTIES REGARDING PRESERVATION OF COLLATERAL. The
Secured Parties' sole duty with respect to the custody, safekeeping and physical
preservation of the Collateral in its possession, under Article 9 or otherwise,
shall be to deal with it in the same manner as any Secured Party deals with
similar property for its own account. None of the Secured Parties nor any of
their respective directors, officers, agents or employees shall be liable for
failure to demand, collect or realize upon all or any part of the Collateral or
for any delay in doing so or shall be under any obligation to sell or otherwise
dispose of any Collateral upon the request of Debtor or otherwise.

      11.   POWERS COUPLED WITH AN INTEREST. All authorizations and agencies
herein contained with respect to the Collateral are irrevocable and powers
coupled with an interest.

      12.   SEVERABILITY. Any provision of this Security Agreement that is
prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction. All covenants and other
agreements contained in this Security Agreement by or on behalf of any of the
parties hereto bind and inure to the benefit of their respective successors and
assigns whether so expressed or not.

      13.   PARAGRAPH HEADINGS. The paragraph headings used in this Security
Agreement are for convenience of reference only and are not to affect the
construction hereof or be taken into consideration in the interpretation hereof.
This Security Agreement may be executed in any number of counterparts, each of
which shall be an original but all of which together shall constitute one
instrument. Each counterpart may consist of a number of copies hereof, each
signed by less than all, but together signed by all, of the parties hereto.


                                       13



      14.   NO WAIVER; CUMULATIVE REMEDIES. The Secured Parties shall not, by
any act (except by a written instrument), delay, indulgence, omission or
otherwise, be deemed to have waived any right or remedy hereunder or to have
acquiesced in any default or in any breach of any of the terms and conditions
hereof. No failure to exercise, nor any delay in exercising, on the part of any
of the Secured Parties, any right, power or privilege hereunder shall operate as
a waiver thereof. No single or partial exercise of any right, power or privilege
hereunder shall preclude any other or further exercise thereof or the exercise
of any other right, power or privilege. A waiver by any Secured Party of any
right or remedy hereunder on any one occasion shall not be construed as a bar to
any right or remedy that the Secured Parties would otherwise have on any future
occasion. The rights and remedies herein provided are cumulative, may be
exercised singly or concurrently and are not exclusive of any rights or remedies
provided by law. THIS SECURITY AGREEMENT SHALL BE CONSTRUED AND ENFORCED IN
ACCORDANCE WITH, AND THE RIGHTS OF THE PARTIES SHALL BE GOVERNED BY, THE LAW OF
THE STATE OF NEW YORK EXCLUDING CHOICE-OF-LAW PRINCIPLES OF THE LAW OF SUCH
STATE THAT WOULD REQUIRE THE APPLICATION OF THE LAWS OF A JURISDICTION OTHER
THAN SUCH STATE.

      15.   JURISDICTION; VENUE; SERVICE OF PROCESS. This Agreement shall be
subject to the exclusive jurisdiction of the Federal District Court, Southern
District of New York and if such court does not have proper jurisdiction, the
State Courts of New York County, New York. The parties to this Agreement agree
that any breach of any term or condition of this Agreement shall be deemed to be
a breach occurring in the State of New York by virtue of a failure to perform an
act required to be performed in the State of New York and irrevocably and
expressly agree to submit to the jurisdiction of the Federal District Court,
Southern District of New York and if such court does not have proper
jurisdiction, the State Courts of New York County, New York for the purpose of
resolving any disputes among the parties relating to this Agreement or the
transactions contemplated hereby. The parties irrevocably waive, to the fullest
extent permitted by law, any objection which they may now or hereafter have to
the laying of venue of any suit, action or proceeding arising out of or relating
to this Agreement, or any judgment entered by any court in respect hereof
brought in New York County, New York, and further irrevocably waive any claim
that any suit, action or proceeding brought in Federal District Court, Southern
District of New York and if such court does not have proper jurisdiction, the
State Courts of New York County, New York has been brought in an inconvenient
forum. Each of the parties hereto consents to process being served in any such
suit, action or proceeding, by mailing a copy thereof to such party at the
address in effect for notices to it under this Agreement and agrees that such
service shall constitute good and sufficient service of process and notice
thereof. Nothing in this Section 15 shall affect or limit any right to serve
process in any other manner permitted by law.

      16.   NOTICES. Notices hereunder shall be given to the Debtor and each
Secured Party in the manner set forth in the Purchase Agreement of even date
herewith between the Debtor and each of the Secured Parties and at the addresses
set forth therein.

      17.   TERMINATION. Upon the repayment in full of all Obligations, this
Security Agreement shall terminate, the Secured Parties shall deliver any
release of the Encumbrances created under this Security Agreement that Debtor
may reasonably request (at the cost of the Debtor), and the Secured Parties
shall return to the Debtor all Collateral then in its possession,


                                       14



custody, or control, and this Security Agreement shall terminate without further
action by the Party and be of no further force and effect.

               [intentionally left blank - signature page follows]

      IN WITNESS WHEREOF, the parties hereto have caused this Security Agreement
to be duly executed and delivered as of the date first above written.



                                 ACCESS PHARMACEUTICALS, INC.


                                 By: /s/ Stephen B. Thompson
                                     -------------------------------------------
                                     Name:  Stephen B. Thompson
                                     Title: Vice President, CFO


                                       15



                            OMNIBUS SIGNATURE PAGE TO
                          ACCESS PHARMACEUTICALS, INC.
                               SECURITY AGREEMENT

The undersigned, as a Secured Party, hereby executes and delivers the Security
Agreement to which this signature page is attached, which, together with all
counterparts of the Security Agreement and signature pages of the other parties
named in said Security Agreement, shall constitute one and the same document in
accordance with the terms of the Security Agreement.


                                 Print Name:   SCO Capital Partners LLC
                                            ------------------------------------


                                 By:           /s/ Steven H. Rouhandeh
                                            ------------------------------------
                                 Name:         Steven H. Rouhandeh
                                            ------------------------------------
                                 Title:        Chairman
                                            ------------------------------------


                                       16



                            OMNIBUS SIGNATURE PAGE TO
                          ACCESS PHARMACEUTICALS, INC.
                               SECURITY AGREEMENT

The undersigned, as a Secured Party, hereby executes and delivers the Security
Agreement to which this signature page is attached, which, together with all
counterparts of the Security Agreement and signature pages of the other parties
named in said Security Agreement, shall constitute one and the same document in
accordance with the terms of the Security Agreement.


                                 Print Name:   Beach Capital LLC
                                            ------------------------------------


                                 By:           /s/ Steven H. Rouhandeh
                                            ------------------------------------
                                 Name:         Steven H. Rouhandeh
                                            ------------------------------------
                                 Title:        Managing Member
                                            ------------------------------------


                                       17




                            OMNIBUS SIGNATURE PAGE TO
                          ACCESS PHARMACEUTICALS, INC.
                               SECURITY AGREEMENT

The undersigned, as a Secured Party, hereby executes and delivers the Security
Agreement to which this signature page is attached, which, together with all
counterparts of the Security Agreement and signature pages of the other parties
named in said Security Agreement, shall constitute one and the same document in
accordance with the terms of the Security Agreement.


                                 Print Name:   Lake End Capital LLC
                                            ------------------------------------


                                 By:           /s/ Jeffrey B. Davis
                                            ------------------------------------
                                 Name:         Jeffrey B. Davis
                                            ------------------------------------
                                 Title:        Managing Member
                                            ------------------------------------


                                       18