X0202 4 2004-12-01 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001225199 GODDARD COLIN C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 1 1 0 0 Chief Executive Officer Common Stock 2004-12-01 4 M 0 8300 6.875 A 42499 D Common Stock 2004-12-01 4 S 0 141 47.95 D 42358 D Common Stock 2004-12-01 4 S 0 704 47.97 D 41654 D Common Stock 2004-12-01 4 S 0 423 47.98 D 41231 D Common Stock 2004-12-01 4 S 0 235 47.99 D 40996 D Common Stock 2004-12-01 4 S 0 422 48.00 D 40574 D Common Stock 2004-12-01 4 S 0 563 48.01 D 40011 D Common Stock 2004-12-01 4 S 0 423 48.02 D 39588 D Common Stock 2004-12-01 4 S 0 94 48.03 D 39494 D Common Stock 2004-12-01 4 S 0 365 48.29 D 39129 D Common Stock 2004-12-01 4 S 0 797 48.37 D 38332 D Common Stock 2004-12-01 4 S 0 423 48.40 D 37909 D Common Stock 2004-12-01 4 S 0 94 48.41 D 37815 D Common Stock 2004-12-01 4 S 0 47 48.45 D 37768 D Common Stock 2004-12-01 4 S 0 1033 48.50 D 36735 D Common Stock 2004-12-01 4 S 0 847 48.57 D 35888 D Common Stock 2004-12-01 4 S 0 470 48.58 D 35418 D Common Stock 2004-12-01 4 S 0 46 48.60 D 35372 D Common Stock 2004-12-01 4 S 0 46 48.64 D 35326 D Common Stock 2004-12-01 4 S 0 845 48.65 D 34481 D Common Stock 2004-12-01 4 S 0 235 48.66 D 34246 D Common Stock 2004-12-01 4 S 0 47 48.74 D 34199 D Stock Option (Right to Buy) 6.875 2004-12-01 4 M 0 8300 0.00 D 1998-06-11 2007-06-10 Common Stock 8300 41000 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. One third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2004-12-03