X0202 4 2006-08-25 0000729922 OSI PHARMACEUTICALS INC OSIP 0001225199 GODDARD COLIN C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 1 Chief Executive Officer Common Stock 2006-08-25 2006-08-25 4 M 0 30000 7.875 A 105273 D Common Stock 2006-08-25 2006-08-25 4 S 0 1000 35.75 D 104273 D Common Stock 2006-08-25 2006-08-25 4 S 0 230 35.79 D 104043 D Common Stock 2006-08-25 2006-08-25 4 S 0 1400 35.8 D 102643 D Common Stock 2006-08-25 2006-08-25 4 S 0 819 35.81 D 101824 D Common Stock 2006-08-25 2006-08-25 4 S 0 204 35.82 D 101620 D Common Stock 2006-08-25 2006-08-25 4 S 0 400 35.83 D 101220 D Common Stock 2006-08-25 2006-08-25 4 S 0 1400 35.84 D 99820 D Common Stock 2006-08-25 2006-08-25 4 S 0 300 35.85 D 99520 D Common Stock 2006-08-25 2006-08-25 4 S 0 100 35.87 D 99420 D Common Stock 2006-08-25 2006-08-25 4 S 0 3047 35.89 D 96373 D Common Stock 2006-08-25 2006-08-25 4 S 0 1100 35.93 D 95273 D Common Stock 2006-08-25 2006-08-25 4 S 0 672 36.05 D 94601 D Common Stock 2006-08-25 2006-08-25 4 S 0 11 36.06 D 94590 D Common Stock 2006-08-25 2006-08-25 4 S 0 208 36.07 D 94382 D Common Stock 2006-08-25 2006-08-25 4 S 0 228 36.08 D 94154 D Common Stock 2006-08-25 2006-08-25 4 S 0 100 36.09 D 94054 D Common Stock 2006-08-25 2006-08-25 4 S 0 600 36.11 D 93454 D Common Stock 2006-08-25 2006-08-25 4 S 0 1200 36.13 D 92254 D Common Stock 2006-08-25 2006-08-25 4 S 0 600 36.14 D 91654 D Common Stock 2006-08-25 2006-08-25 4 S 0 6500 36.15 D 85154 D Common Stock 2006-08-25 2006-08-25 4 S 0 200 36.16 D 84954 D Common Stock 2006-08-25 2006-08-25 4 S 0 217 36.18 D 84737 D Common Stock 2006-08-25 2006-08-25 4 S 0 3564 36.2 D 81173 D Common Stock 2006-08-25 2006-08-25 4 S 0 800 36.21 D 80373 D Common Stock 2006-08-25 2006-08-25 4 S 0 350 36.22 D 80023 D Common Stock 2006-08-25 2006-08-25 4 S 0 600 36.23 D 79423 D Common Stock 2006-08-25 2006-08-25 4 S 0 300 36.27 D 79123 D Common Stock 2006-08-25 2006-08-25 4 S 0 800 36.28 D 78323 D Common Stock 2006-08-25 2006-08-25 4 S 0 300 36.29 D 78023 D Stock Option (Right to Buy) 7.875 2006-08-25 2006-08-25 4 M 0 30000 0 D 1997-09-25 2006-09-25 Common Stock 30000 0 D Transaction made pursuant to a 10b5-1 plan dated March 16, 2006. Transaction occurred upon exercise of option due to expire on September 25, 2006. One third of the stock option became exercisable one year after the date of the grant and the remainder vested on a monthly basis in 23 equal installments of 833 shares with the final vesting of 841 shares on the 24th month. Form 1 of 2 /s/ Michael G. Atieh, attorney-in-fact for Dr. Goddard 2006-08-29