X0202 SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 1 Common Stock, $0.001 par value per share 03/31/2026 0001439725 BIODESIX, INC. 09075X207 919 West Dillon Rd Louisville CO 80027 Rule 13d-1(c) Perceptive Advisors LLC b DE 0 483694 0 483694 483694 N 4.6 IA Joseph Edelman b X1 0 483694 0 483694 483694 N 4.6 IN Perceptive Credit Advisors LLC b DE 0 483694 0 483694 483694 N 4.6 IA PCOF EQ AIV IV, LP b DE 0 51828 0 51828 51828 N 0.5 PN Perceptive Credit Holdings IV, LP b DE 0 431866 0 431866 431866 N 4.1 PN BIODESIX, INC. 919 West Dillon Rd Louisville, Colorado 80027 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.001 par value per share (the "Common Stock") of Biodesix, Inc. (the "Issuer") are: Perceptive Advisors LLC ("Perceptive Advisors") Joseph Edelman ("Mr. Edelman") Perceptive Credit Advisors LLC ("Perceptive Credit") PCOF EQ AIV IV, LP (the "Opportunity Fund") Perceptive Credit Holdings IV, LP (the "Credit Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. Perceptive Credit is a Delaware limited liability company. The Opportunity Fund is a Delaware limited partnership. The Credit Fund is a Delaware limited partnership. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 10,108,580 shares of Common Stock outstanding as of April 29, 2026, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 4, 2026 and give effect to the exercise of the Warrants (as defined below). The Credit Fund directly holds (i) 56,866 shares of Common Stock and (ii) 375,000 warrants to purchase shares of Common Stock (the "Warrants"). The Opportunity Fund directly holds 51,828 shares of Common Stock. The Warrants may not be exercised if the Reporting Persons would beneficially own more than 9.99% of the Issuer's outstanding shares of Common Stock after giving effect to such exercise. Accordingly, the Credit Fund and Opportunity Fund could currently exercise all of their Warrants. Perceptive Credit serves as the investment manager to each of the Credit Fund and Opportunity Fund and as relying advisor under Perceptive Advisors. Perceptive Credit Opportunities GP, LLC serves as the general partner of the Credit Fund. PCOF EQ AIV GP, LLC serves as the general partner of the Opportunity Fund. Mr. Edelman is the managing member of Perceptive Advisors. Each of Perceptive Advisors, Perceptive Credit and Mr. Edelman may be deemed to beneficially own the securities of the Issuer held by the Credit Fund and the Opportunity Fund. Perceptive Advisors: 4.6% Mr. Edelman: 4.6% Perceptive Credit: 4.6% The Opportunity Fund: 0.5% The Credit Fund: 4.1% Perceptive Advisors: 0 Mr. Edelman: 0 Perceptive Credit: 0 The Opportunity Fund: 0 The Credit Fund: 0 Perceptive Advisors: 483,694 Mr. Edelman: 483,694 Perceptive Credit: 483,694 The Opportunity Fund: 51,828 The Credit Fund: 431,866 Perceptive Advisors: 0 Mr. Edelman: 0 Perceptive Credit: 0 The Opportunity Fund: 0 The Credit Fund: 0 Perceptive Advisors: 483,694 Mr. Edelman: 483,694 Perceptive Credit: 483,694 The Opportunity Fund: 51,828 The Credit Fund: 431,866 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/15/2026 Joseph Edelman /s/ Joseph Edelman 05/15/2026 Perceptive Credit Advisors LLC /s/ Joseph Edelman 05/15/2026 PCOF EQ AIV IV, LP /s/ Joseph Edelman 05/15/2026 Perceptive Credit Holdings IV, LP /s/ Joseph Edelman 05/15/2026