SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 per share 12/31/2025 0001689548 Praxis Precision Medicines, Inc. 74006W207 99 High Street, 30th Floor Boston MA 02110 Rule 13d-1(c) Perceptive Advisors LLC b DE 0 1995986 0 1995986 1995986 N 7.2 IA Joseph Edelman b X1 0 1995986 0 1995986 1995986 N 7.2 IN Perceptive Life Sciences Master Fund, Ltd. b E9 0 1995986 0 1995986 1995986 N 7.2 CO Praxis Precision Medicines, Inc. 99 High Street, 30th Floor, Boston, MA 02110 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.0001 per share (the "Common Stock") of Praxis Precision Medicines, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 27,738,892 shares of Common Stock outstanding as reported in the Issuer's Prospectus Supplement filed pursuant to Rule 424(b)(5) with the Securities and Exchange Commission on January 7, 2026. The Master Fund directly holds 1,995,986 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors. Perceptive Advisors: 7.2% Mr. Edelman: 7.2% Master Fund: 7.2% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,995,986 Mr. Edelman: 1,995,986 Master Fund: 1,995,986 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,995,986 Mr. Edelman: 1,995,986 Master Fund: 1,995,986 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 02/17/2026 Joseph Edelman /s/ Joseph Edelman 02/17/2026 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 02/17/2026