X0508 4 2023-10-16 0001805387 Cerevel Therapeutics Holdings, Inc. CERE 0001224962 PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 0 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 0 0 0001164426 EDELMAN JOSEPH 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 0 0 0 Common Stock 2023-10-16 4 P 0 876808 22.81 A 10794876 I See Footnote Common Stock 170317 I See Footnote Includes 3,406,341 shares of common stock the Master Fund (as defined below) received pursuant to a liquidation distribution by ARYA Sciences Holdings II on April 11, 2023 (the "Liquidation Distribution"). The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Mr. Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. Represents 170,317 shares of common stock received by Mr. Edelman on April 11, 2023 pursuant to a distribution by Perceptive SP(A), L.P. (the "Co-Investment Fund") which the Co-Investment Fund received pursuant to the Liquidation Distribution. The securities are directly held by C2 Life Sciences, LLC ("C2"). The Advisor serves as the investment manager of C2 and Mr. Edelman is the managing member of the Advisor. /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member 2023-10-17 /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2023-10-17 /s/ Joseph Edelman 2023-10-17