X0306 4 2022-06-07 0001735438 MeiraGTx Holdings plc MGTX 0001224962 PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 0001164426 EDELMAN JOSEPH 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 Stock Option (right to buy) 8.25 2022-06-07 4 A 0 15000 0 A 2032-06-07 Ordinary Shares 15000 15000 I See Footnote Restricted Share Units 2022-06-07 4 A 0 15000 0 A Ordinary Shares 15000 15000 I See Footnote The option shall vest and become exercisable in a single annual installment upon the earliest of (1) June 7, 2023 or (2) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2023. Each restricted share unit converts into one ordinary share of the Issuer upon settlement. The restricted share units become settlable when Ellen Hukkelhoven ceases to be a director of the Issuer. Ms. Hukkelhoven is a Managing Director of Perceptive Advisors, LLC (the "Advisor"). The restricted share units shall vest in a single annual installment upon the earlier of (1) June 7, 2023 or (2) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2023. The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2022-06-13 /s/ Joseph Edelman 2022-06-13