The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABBOTT LABORATORIESCOM0028241001,92150,000SH SOLE 000
ABEONA THERAPEUTICSCOM00289Y1074,085842,173SH SOLE 000
ABEONA THERAPEUTICS CW-19WARRANTS00289y1153,7781,259,636SH SOLE 000
ABIOMEDCOM00365410012109SH SOLE 000
ACORDA THERAPEUTICSCOM00484M10613,536720,000SH SOLE 000
ACADIA PHARMACEUTICALS INC CALL 40 01/20/2017COM00422510805,200SHCallSOLE 000
ACADIA PHARMACEUTICALS INC CALL 40 01/20/2017COM004225108794,800SHCallSOLE 000
ACASTI PHARMA CLASS ACOM00430K402233186,559SH SOLE 000
ACCELERON PHARMACOM00434H10815,822619,987SH SOLE 000
ACCRETIVE HEALTHCOM00438V103709315,000SH SOLE 000
ACELRX PHARMACEUTICALSCOM00444T10014,0635,408,728SH SOLE 000
ACLARIS THERAPEUTICSCOM00461U10534,2191,260,847SH SOLE 000
ADMA BIOLOGICSCOM0008991043,692721,102SH SOLE 000
AEGLEA BIOTHERAPEUTICSCOM00773J103451103,585SH SOLE 000
AERIE PHARMACEUTICALSCOM00771V1081,89350,000SH SOLE 000
AEVI GENOMIC MEDICINE WARRANTWARRANTS58436Q120106150,000SH SOLE 000
AEVI GENOMIC MEDICINECOM00835P1051,520293,460SH SOLE 000
AFFIMEDCOMN010451081,322734,301SH SOLE 000
AGENUSCOM00847G70529772,187SH SOLE 000
AGILE THERAPEUTICSCOM00847L1003,770661,446SH SOLE 000
AKEBIA THERAPEUTICSCOM00972D1055,593537,256SH SOLE 000
ALDER BIOPHARMACEUTICALSCOM0143391057,991384,169SH SOLE 000
ALDEYRA THERAPEUTICSCOM01438T10610,3811,940,458SH SOLE 000
ALLIQUA BIOMEDICALCOM0196212001,1331,921,951SH SOLE 000
ALLON THERAPEUTICSCOM0197741080751,124SH SOLE 000
ALNYLAM PHARMACEUTICALSCOM02043Q1074,436118,475SH SOLE 000
AMAG PHARMACEUTICALSCOM00163U10667919,524SH SOLE 000
AMICUS THERAPEUTICSCOM03152W10985,96417,296,672SH SOLE 000
AMN HEALTHCARECOM00174410148412,585SH SOLE 000
ANI PHARMACEUTICALSCOM00182C10316,192267,100SH SOLE 000
ANI PHARMACEUTICALS INC 01DEC19 3.0PCTNOTE00182CAA18,7007,500,000PRN SOLE 000
ANTARES PHARMACOM0366421066,7972,917,253SH SOLE 000
APPLIED GENETIC TECHNOLOGIESCOM03820J10047050,251SH SOLE 000
APTEVO THERAPEUTICSCOM03835L1082,411988,133SH SOLE 000
ARDELYXCOM03969710726,0731,836,196SH SOLE 000
ARIAD PHARMACEUTICALSCOM04033A100191,551SH SOLE 000
ARNO THERAPEUTICS INCCOM0425642037814,177,577SH SOLE 000
ARROWHEAD Pharmaceuticalscom04280a1001,313847,458SH SOLE 000
ASSEMBLY BIOSCIENCESCOM0453961088,679714,354SH SOLE 000
ATRICURECOM04963C2091,84794,400SH SOLE 000
AUDENTES THERAPEUTICSCOM05070R1041377,500SH SOLE 000
AVADEL PHARMACEUTICALSCOM05337M10414,4241,388,240SH SOLE 000
AVEO PHARMACEUTICALSCOM0535881091,6783,108,808SH SOLE 000
AVEXISCOM05366U10022,602473,531SH SOLE 000
AVINGERCOM05373410941,062SH SOLE 000
AZURRX BIOPHARMACOM05502L1051,077227,272SH SOLE 000
BARCLAYS BANK IPATH SandP 500 VIX SHORT TERM FUTURES ETN EXPCOM06740Q2521,04641,000SH SOLE 000
BIO RAD LABORATORIES CLASS ACOM0905722074,45124,416SH SOLE 000
BIOCRYST PHARMACEUTICALSCOM09058V1038,4201,330,240SH SOLE 000
BIOGEN INCCOM09062X1035451,922SH SOLE 000
BIOMARIN PHARMACEUTICALCOM09061G10121250SH SOLE 000
BLUEPRINT MEDICINESCOM09627Y1097,680273,820SH SOLE 000
BOSTON SCIENTIFICCOM10113710703SH SOLE 000
BRAINSTORM CELL THERAPEUTICSCOM10501E2011,016400,000SH SOLE 000
BRUKERCOM11679410803SH SOLE 000
CAPITAL SENIOR LIVINGCOM1404751045,222320,173SH SOLE 000
CAPRICOR THERAPEUTICSCOM14070B101114,000SH SOLE 000
CASCADIAN THERAPEUTICSCOM14740B6062,355546,498SH SOLE 000
CATALENTCOM14880610203SH SOLE 000
CELGENECOM1510201043,01026,000SH SOLE 000
CEMPRACOM15130J1096222,321SH SOLE 000
CHAMPIONS ONCOLOGYCOM15870P307942372,597SH SOLE 000
CHINA BIOLOGIC PRODUCTSCOM16938C10625236SH SOLE 000
CIDARA THERAPEUTICSCOM1717571078,043773,369SH SOLE 000
CLEARSIDE BIOMEDICALCOM1850631046,365712,062SH SOLE 000
CLOVIS ONCOLOGYCOM1894641007,452167,754SH SOLE 000
COLLEGIUM PHARMACEUTICALCOM19459J1043,063196,728SH SOLE 000
COLUCID PHARMACEUTICALSCOM19716T10123,346641,364SH SOLE 000
CORBUS PHARMACEUTICALS HOLDINGS INC CALL 15 01/20/2017COM21833P10301,600SHCallSOLE 000
CORBUS PHARMACEUTICALS HOLDINGS INCCOM21833P1039,5711,132,684SH SOLE 000
CROSS COUNTRY HEALTHCARECOM22748310454434,819SH SOLE 000
CRYOLIFECOM2289031002123SH SOLE 000
CYNOSURE CLASS ACOM232577205821,800SH SOLE 000
CYTOMX THERAPEUTICSCOM23284F10510,152923,763SH SOLE 000
DANAHERCOM23585110203SH SOLE 000
DAVITACOM23918K10803SH SOLE 000
DBV TECHNOLOGIES ADR REPRESENTING 0.5COM23306J10121,452610,643SH SOLE 000
DERMIRACOM24983L1049,875325,583SH SOLE 000
DYNAVAX TECHNOLOGIES CALL 4 01/2017COM268158201515,600SHCallSOLE 000
EAGLE PHARMACEUTICALSCOM26979610839,527498,198SH SOLE 000
EIGER BIOPHARMACEUTICALSCOM28249U1051,836157,679SH SOLE 000
ELI LILLY & CO CALL 90 01/20/2017COM5324571083100,000SHCallSOLE 000
ENDO INTERNATIONALCOMG3040110621312,920SH SOLE 000
ENZO BIOCHEMCOM29410010258283,893SH SOLE 000
EVOLENT HEALTH CLASS ACOM30050B1014,555307,800SH SOLE 000
EXACT SCIENCES CORP PUT 17 01/20/2017COM30063P105670200,000SHPutSOLE 000
EXELIXISCOM30161Q10469146,361SH SOLE 000
EXPRESS SCRIPTS HOLDINGCOM30219G1084576,639SH SOLE 000
FERRARICOMN3167Y1033606,200SH SOLE 000
FIAT CHRYSLER AUTOMOBILESCOMN3173810256562,000SH SOLE 000
FIVE PRIME THERAPEUTICSCOM33830X1048,181163,255SH SOLE 000
FIVE STAR QUALITY CARECOM33832D10618367,797SH SOLE 000
FLEX PHARMACOM33938A1051237SH SOLE 000
FOAMIX PHARMACEUTICALSCOMM4613510514,6851,322,994SH SOLE 000
FORWARD PHARMA ADR REPRESENTING 1COM34986J1055,918394,241SH SOLE 000
GALAPAGOS ADR REPRESENTINGCOM36315X10120,631304,531SH SOLE 000
GENVECCOM37246C40618056,131SH SOLE 000
GLAUKOSCOM37732210210300SH SOLE 000
GLOBAL BLOOD THERAPEUTICSCOM37890U10845,2133,128,978SH SOLE 000
HILL ROM HOLDINGSCOM4314751024457,930SH SOLE 000
HISTOGENCIS CORPCOM43358V1092,9681,777,777SH SOLE 000
HUMANACOM4448591024542,227SH SOLE 000
HUMANA INC CALL 210 04/21/2017COM44485910252840,000SHCallSOLE 000
ICONCOMG4705A1005176,873SH SOLE 000
IGNYTACOM451731103356,584SH SOLE 000
IMMUNE DESIGNCOM45252L10342877,725SH SOLE 000
IMPAX LABORATORIESCOM45256B10101SH SOLE 000
INC RESEARCH HOLDINGS CLASS ACOM45329R10966512,636SH SOLE 000
INCYTECOM45337C1025635,619SH SOLE 000
INNOCOLLCOMG4783X10579,433SH SOLE 000
INOGENCOM45780L1048125SH SOLE 000
INTELLIA THERAPEUTICSCOM45826J10519214,673SH SOLE 000
INVITAECOM46185L1033,970500,000SH SOLE 000
IRHYTHM TECHNOLOGIESCOM45005610610,567352,241SH SOLE 000
IRIDEXCOM46268410130821,885SH SOLE 000
ISHARES 20 PLUS YEAR TREASURY BOND ETFNOTE46428743202PRN SOLE 000
ISHARES CORE SandP 500 ETFCOM46428720001SH SOLE 000
ISHARES RUSSELL MID-CAP VALUE ETFCOM46428747302SH SOLE 000
JAZZ PHARMACEUTICALSCOMG508711055,67052,000SH SOLE 000
JOHNSON and JOHNSONCOM47816010402SH SOLE 000
KADMONCOM48283N10611,8212,209,657SH SOLE 000
LA JOLLA PHARMACEUTICALCOM50345960423,1271,319,274SH SOLE 000
LANTHEUS HOLDINGSCOM51654410346253,763SH SOLE 000
LION BIOTECHNOLOGIES INCCOM53619R10224,7943,567,553SH SOLE 000
LHC GROUPCOM50187A1072174,745SH SOLE 000
MAGELLAN HEALTHCOM5590792075657,508SH SOLE 000
MCKESSONCOM58155Q1034323,078SH SOLE 000
MEDICINES CO PUT 32 04/21/2017COM5846881051,070200,000SHPutSOLE 000
MERRIMACK PHARMACEUTICALSCOM59032810020048,910SH SOLE 000
METASTAT INCCOM59140A203618500,000SH SOLE 000
MGC DIAGNOSTICSCOM5527681032,602329,733SH SOLE 000
MINERVA NEUROSCIENCES INCCOM6033801069,523810,537SH SOLE 000
MIRATI THERAPEUTICSCOM60468T1052521SH SOLE 000
MOLINA HEALTHCARECOM60855R1003796,981SH SOLE 000
MYOKARDIACOM62857M1058,089624,694SH SOLE 000
MYOVANT SCIENCESCOMG637AM1022,815226,322SH SOLE 000
NEOS THERAPEUTICSCOM64052L10661,056SH SOLE 000
NEPTUNE TECHNOLOGIES AND BIORESOURCESCOM64077P1086,0046,519,634SH SOLE 000
NEUROCRINE BIOSCIENCESCOM64125C109128,3493,316,523SH SOLE 000
NEURODERMCOMM742311071,28457,825SH SOLE 000
NIVALIS THERAPEUTICSCOM65481J109274122,275SH SOLE 000
NOVAVAXCOM670002104423335,413SH SOLE 000
NXSTAGE MEDICALCOM67072V10350,5331,927,989SH SOLE 000
ONCOBIOLOGICSCOM68235M1053,7591,248,990SH SOLE 000
ONCOBIOLOGICS INC WTSW EXP 2/18/201768235M121518656,382SH SOLE 000
ONCOBIOLOGICS INC WTSW EXP 2/18/201768235M113124656,382SH SOLE 000
OPHTHOTECH CORP CALL 55 01/20/2017COM683745103020,000SHCallSOLE 000
OPHTHOTECH CORP CALL 70 01/20/2017COM6837451030400SHCallSOLE 000
OPHTHOTECH CORP CALL 75 01/20/2017COM6837451035200,000SHCallSOLE 000
OPHTHOTECH CORP PUT 20 01/20/2017COM683745103241,600SHPutSOLE 000
PEREGRINE PHARMACEUTICALSCOM713661304824,332SH SOLE 000
PEREGRINE PHARMACEUTICALS INC 10.5COM7136614033,982200,000SH SOLE 000
PERNIX THERAPEUTICS HOLD 01APR21 4.25PCTNote71426VAK42461,000,000PRN SOLE 000
PFENEXCOM7170711048,293914,376SH SOLE 000
PFIZERCOM7170811031,78655,000SH SOLE 000
PHASERXCOM71723F103310200,000SH SOLE 000
PROTEON THERAPEUTICSCOM74371L109635334,116SH SOLE 000
PSIVIDACOM74440J1013,8982,279,706SH SOLE 000
PSYCHEMEDICSCOM7443752051646,626SH SOLE 000
PUMA BIOTECHNOLOGYCOM74587V1072257,344SH SOLE 000
QUORUM HEALTHCOM74909e106731100,604SH SOLE 000
QUOTIENTCOMG7326810713,8152,854,486SH SOLE 000
RA PHARMACEUTICALSCOM74933V1082,506165,000SH SOLE 000
RADIUS HEALTHCOM75046920710,035263,872SH SOLE 000
REGENXBIOCOM75901B10723,7861,282,286SH SOLE 000
RETROPHINCOM76129910650,8722,687,412SH SOLE 000
SANGAMO BIOSCIENCESCOM8006771061272SH SOLE 000
SAREPTA THERAPEUTICSCOM80360710075,9762,769,829SH SOLE 000
SAREPTA THERAPEUTICS INC PUT 50 01/20/2017COM80360710024910,900SHPutSOLE 000
SCYNEXISCOM811292101546171,185SH SOLE 000
SELECTA BIOSCIENCESCOM8162121042,433141,875SH SOLE 000
SEVION THERAPEUTICS INCCOM81834Q104859,220SH SOLE 000
SPDR DOW JONES INDUSTRIAL AVERAGE ETFCOM78467X10913SH SOLE 000
SPDR GOLD SHARES ETFCOM78463V10701SH SOLE 000
SPDR SandP BIOTECH ETFCOM78464A870350SH SOLE 000
STEMLINE THERAPEUTICSCOM85858C10711510,702SH SOLE 000
SUCAMPO PHARMACEUTICALS CLASS ACOM86490910641630,694SH SOLE 000
SUPERNUS PHARMACEUTICALSCOM86845910811421SH SOLE 000
SYNERGY PHARMACEUTICALSCOM8716393082,986490,300SH SOLE 000
TENGION INCCOM88034G20811,826,399SH SOLE 000
TESAROCOM88156910792,521687,993SH SOLE 000
THERAPEUTICSMDCOM88338N1071,731300,000SH SOLE 000
THERMO FISHER SCIENTIFICCOM88355610202SH SOLE 000
TRACON PHARMACEUTICALSCOM89237H100490100,000SH SOLE 000
UNIQURECOMN900641017,0891,265,963SH SOLE 000
UNITED THERAPEUTICSCOM91307C1026824,753SH SOLE 000
UNITEDHEALTH GROUPCOM91324P1025163,223SH SOLE 000
VBI VACCINESCOM91822J10320,3546,565,843SH SOLE 000
VERICELCOM92346J108289,385SH SOLE 000
VERSARTISCOM92529L10261,8894,153,685SH SOLE 000
VERTEX PHARMACEUTICALSCOM92532F1006,29985,509SH SOLE 000
WAVE LIFE SCIENCESCOMY9530810518,088665,198SH SOLE 000
WELLCARE HEALTHCARE PLANSCOM94946T1066935,056SH SOLE 000
WEST PHARMACEUTICAL SERVICESCOM95530610512138SH SOLE 000
XENCORCOM98401F10546,9821,785,018SH SOLE 000
XENON PHARMACEUTICALSCOM98420N1055,700740,272SH SOLE 000
ZOETIS CLASS ACOM98978V10303SH SOLE 000
ZOGENIXCOM98978L2049,149752,999SH SOLE 000
ZYNERBA PHARMACEUTICALSCOM98986X10913,128842,128SH SOLE 000