The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 2824100 120 3,040 SH   SOLE   0 0 0
ABBVIE INC COM 00287Y109 77 1,250 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC *W EXP 12/19/201 00289Y115 1,071 1,259,636 SH   SOLE   0 0 0
Abeona Therapeutics Inc COM 00289Y107 4,159 1,762,881 SH   SOLE   0 0 0
ABIOMED INC COM 3654100 1,607 14,700 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 4225108 5,364 165,240 SH   SOLE   0 0 0
ACASTI PHARMA INC CL A NEW 00430K402 336 236,559 SH   SOLE   0 0 0
ACCELERON COM 00434H108 20,491 603,036 SH   SOLE   0 0 0
ACELRX PHARMA COM 00444T100 16,129 5,995,760 SH   SOLE   0 0 0
ADMA BIOLOGICS INC COM 899104 2,371 398,394 SH   SOLE   0 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 515 105,893 SH   SOLE   0 0 0
AETNA INC NEW COM 00817Y108 544 4,454 SH   SOLE   0 0 0
AFFIMED N V COM N01045108 1,821 734,301 SH   SOLE   0 0 0
AGILE THERAPEUTICS INC COM 00847L100 3,914 514,288 SH   SOLE   0 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 70 6,448 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 6,684 893,600 SH   SOLE   0 0 0
ALCOBRA LTD SHS M2239P109 4,617 1,028,272 SH   SOLE   0 0 0
ALDER BIOPHARMACEUTICALS INC COM 14339105 9,988 400,000 SH   SOLE   0 0 0
ALDEYRA COM 01438T106 11,041 1,940,458 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL INC COM NEW 19621200 2,152 1,921,951 SH   SOLE   0 0 0
ALLON THERAPEUTICS COM 019774108 0 751,124 SH   SOLE   0 0 0
ALMOST FAMILY INC COM 20409108 509 11,942 SH   SOLE   0 0 0
AMERISOURCEBERGEN CORP COM 03073E105 516 6,500 SH   SOLE   0 0 0
AMICUS COM 03152W109 83,207 15,239,444 SH   SOLE   0 0 0
AMN HEALTHCARE SERVICES INC COM 1744101 537 13,445 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC COM 00182C103 3,749 67,161 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/ 00182CAA1 8,121 7,500,000 PRN   SOLE   0 0 0
ANTHEM INC COM 36752103 447 3,400 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 4,611 1,492,156 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 9,309 658,851 SH   SOLE   0 0 0
ARATANA THERAPEUTICS INC COM 03874P101 1,621 256,500 SH   SOLE   0 0 0
ARDELYX INC COM 39697107 2,758 315,955 SH   SOLE   0 0 0
ARNO THERAPEUTIC INC COM 42564203 1,080 3,463,292 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC COM 45396108 4,412 795,000 SH   SOLE   0 0 0
ATARA BIOTHERAPEUTICS INC COM 46513107 56 2,500 SH   SOLE   0 0 0
AVEO PHARMACEUTICALS INC COM 053588109 2,987 3,108,808 SH   SOLE   0 0 0
AVEXIS INC COM 05366U100 58 1,515 SH   SOLE   0 0 0
AVINGER INC COM 53734109 13 1,062 SH   SOLE   0 0 0
AXOVANT SCIENCES LTD COM G0750W104 6,227 485,000 SH   SOLE   0 0 0
BIOTIME INC COM 09066L105 36 13,740 SH   SOLE   0 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 9,404 464,404 SH   SOLE   0 0 0
BRAINSTROM CELL THERAPEUTICS COM 10501E201 964 400,000 SH   SOLE   0 0 0
CAPITAL SR LIVING CORP COM 140475104 10,357 586,136 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 16 4,000 SH   SOLE   0 0 0
CARDINAL HEALTH INC COM 14149Y108 499 6,398 SH   SOLE   0 0 0
Cascadian Therapeutics Inc COM 14740B101 3,220 3,414,121 SH   SOLE   0 0 0
CELATOR PHARMACEUTICALS INC COM 15089R102 25,303 838,400 SH   SOLE   0 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 312 71,124 SH   SOLE   0 0 0
CELLECTIS S A SPONSORED ADS 15117K103 4,879 183,507 SH   SOLE   0 0 0
CEMPRA INC COM 15130J109 2,803 170,000 SH   SOLE   0 0 0
CENTENE CORP DEL COM 15135B101 353 4,948 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 801 372,597 SH   SOLE   0 0 0
CHARLES RIV LABS INTL INC COM 159864107 452 5,482 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 1,488 14,000 SH   SOLE   0 0 0
CIDARA THERAPEUTICS INC COM 171757107 8,174 792,857 SH   SOLE   0 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 4,450 634,808 SH   SOLE   0 0 0
COGENTIX MED INC COM 19243A104 498 517,760 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 9,568 3,200,000 SH   SOLE   0 0 0
CORCEPT THERAPEUTICS INC COM 218352102 60 11,000 SH   SOLE   0 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 7,579 742,021 SH   SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 17,833 546,696 SH   SOLE   0 0 0
DEPOMED INC COM 249908104 11,727 600,000 SH   SOLE   0 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,706 432,884 SH   SOLE   0 0 0
DERMIRA INC COM 24983L104 13,514 462,000 SH   SOLE   0 0 0
DEXCOM INC COM 252131107 9,930 125,174 SH   SOLE   0 0 0
DIGIRAD CORP COM 253827109 129 24,988 SH   SOLE   0 0 0
DIPLOMAT PHARMACY INC COM 25456K101 76 2,175 SH   SOLE   0 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 36 2,499 SH   SOLE   0 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 11,637 300,000 SH   SOLE   0 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,079 104,920 SH   SOLE   0 0 0
ENZO BIOCHEM INC COM 294100102 401 67,113 SH   SOLE   0 0 0
EVOLENT HEALTH INC CL A 30050B101 16,763 873,064 SH   SOLE   0 0 0
FERRARI N V COM N3167Y103 254 6,200 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 379 62,000 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 7,006 169,439 SH   SOLE   0 0 0
FLEX PHARMA INC COM 33938A105 2 237 SH   SOLE   0 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 5,048 795,000 SH   SOLE   0 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 5,658 311,400 SH   SOLE   0 0 0
GENOCEA BIOSCIENCES INC COM 372427104 71 17,313 SH   SOLE   0 0 0
GENVEC INC COM NEW 37246C307 3,447 606,644 SH   SOLE   0 0 0
GLAUKOS CORP COM 377322102 9 300 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 36,625 2,207,668 SH   SOLE   0 0 0
GLOBUS MED INC CL A 379577208 1,192 50,000 SH   SOLE   0 0 0
HCA HOLDINGS INC COM 40412C101 478 6,202 SH   SOLE   0 0 0
HERBALIFE LTD COM USD SHS G4412G101 73 1,250 SH   SOLE   0 0 0
IGNYTA INC COM 451731103 2,359 435,260 SH   SOLE   0 0 0
IMMUNOGEN INC COM 45253H101 79 25,745 SH   SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 514 221,700 SH   SOLE   0 0 0
INNOCOLL HLDGS PLC SHS G4783X105 2,808 560,000 SH   SOLE   0 0 0
INOGEN INC COM 45780L104 6 125 SH   SOLE   0 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 320 15,000 SH   SOLE   0 0 0
Ionis Pharmaceuticals Ord Shs COM 462222100 2,329 100,000 SH Put SOLE   0 0 0
JUNO THERAPEUTICS INC COM 48205A109 43 1,113 SH   SOLE   0 0 0
KINDRED HEALTHCARE INC COM 494580103 478 42,301 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 21,325 1,332,815 SH   SOLE   0 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 520 3,990 SH   SOLE   0 0 0
LANNET INC COM 516012101 634 26,670 SH   SOLE   0 0 0
Lexicon Pharmaceuticals Inc COM 528872302 718 50,000 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 29,257 3,611,976 SH   SOLE   0 0 0
LIPOCINE INC COM 53630X104 865 284,400 SH Put SOLE   0 0 0
LIPOCINE INC COM 53630X104 912 300,000 SH Call SOLE   0 0 0
MAGELLAN HEALTH INC COM NEW 559079207 577 8,772 SH   SOLE   0 0 0
MCKESSON CORP COM 58155Q103 556 2,979 SH   SOLE   0 0 0
MEDGENICS INC COM NEW 58436Q203 1,665 300,000 SH   SOLE   0 0 0
MEDIVATION INC COM 58501N101 45,828 760,000 SH   SOLE   0 0 0
MERRIMACK PHARMACEUTICALS IN COM 590328100 270 50,000 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,193 336,287 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES INC COM 603380106 8,275 810,537 SH   SOLE   0 0 0
MOLINA HEALTHCARE INC COM 60855R100 459 9,200 SH   SOLE   0 0 0
MYLAN N V SHS EURO N59465109 216 5,000 SH   SOLE   0 0 0
MYOKARDIA INC COM 62857M105 6,235 502,894 SH   SOLE   0 0 0
NEOS THERAPEUTICS INC COM 64052L106 4,611 626,876 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 6,885 6,750,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 127,167 2,797,967 SH   SOLE   0 0 0
NEURODERM LTD ORD SHS M74231107 4,388 270,000 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 26,939 365,229 SH   SOLE   0 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 575 125,000 SH   SOLE   0 0 0
NOVAVAX INC COM 670002104 233 32,000 SH   SOLE   0 0 0
NXSTAGE MEDICAL INC COM 67072V103 29,971 1,382,410 SH   SOLE   0 0 0
ONCOBIOLOGICS INC COM 68235M105 4,463 1,312,763 SH   SOLE   0 0 0
ONCOBIOLOGICS INC *W EXP 02/18/201 68235M113 212 462,500 SH   SOLE   0 0 0
ONCOBIOLOGICS INC *W EXP 05/18/201 68235M121 202 462,500 SH   SOLE   0 0 0
OPHTHOTECH CORP COM 683745103 416 8,145 SH   SOLE   0 0 0
PEREGRINE PHARMACEUTICALS IN COM NEW 713661304 81 224,332 SH   SOLE   0 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 200 1,000,000 PRN   SOLE   0 0 0
PFENEX INC COM 717071104 8,043 960,877 SH   SOLE   0 0 0
PHASERX INC COM 71723F103 852 200,000 SH   SOLE   0 0 0
PHIBRO ANIMAL HEALTH CORP CL A COM 71742Q106 453 24,300 SH   SOLE   0 0 0
PROGENICS PHARMACEUTICALS COM 743187106 2,110 500,000 SH Put SOLE   0 0 0
PROTEON THERAPEUTICS INC COM 74371L109 2,208 275,000 SH   SOLE   0 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 3,033 250,000 SH   SOLE   0 0 0
pSivida Corp COM 74440J101 7,542 2,665,000 SH   SOLE   0 0 0
QUOTIENT LTD SHS G73268107 17,430 2,249,067 SH   SOLE   0 0 0
REGENXBIO INC COM 75901B107 8,793 1,099,213 SH   SOLE   0 0 0
RELYPSA INC COM 759531106 1,850 100,000 SH Put SOLE   0 0 0
Retrophin Inc COM 761299106 58,405 3,279,380 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 145,300 7,619,300 SH Put SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 18,673 979,200 SH Call SOLE   0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 71,843 3,767,316 SH   SOLE   0 0 0
SCYNEXIS INC COM 811292101 380 175,000 SH   SOLE   0 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,296 450,000 SH   SOLE   0 0 0
SERES THERAPEUTICS INC COM 81750R102 45 1,540 SH   SOLE   0 0 0
SEVION THERAPEUTICS COM 81834Q104 12 59,220 SH   SOLE   0 0 0
ST JUDE MEDICAL COM 790849103 18,174 233,000 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 532 78,603 SH   SOLE   0 0 0
STREETTRACKS SPDR BIOTEC ETF S&P BIOTECH 78464A870 27,045 500,000 SH Put SOLE   0 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 451 41,096 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 5,093 250,000 SH   SOLE   0 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 448 16,200 SH   SOLE   0 0 0
TENGION INC COM 88034G208 1 1,826,399 SH   SOLE   0 0 0
TESARO INC COM 881569107 4,203 50,000 SH Put SOLE   0 0 0
TESARO INC COM 881569107 96,121 1,143,615 SH   SOLE   0 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 9,845 196,000 SH   SOLE   0 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 3,642 661,041 SH   SOLE   0 0 0
UNIQURE NV SHS N90064101 9,891 1,342,093 SH   SOLE   0 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 503 4,753 SH   SOLE   0 0 0
UNITEDHEALTH GROUP INC COM 91324P102 456 3,231 SH   SOLE   0 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 535 3,989 SH   SOLE   0 0 0
VBI VACCINES INC COM 91790E102 12,080 3,058,433 SH   SOLE   0 0 0
VCA INC COM 918194101 537 7,940 SH   SOLE   0 0 0
VERICEL CORP COM 92346J108 1,254 557,342 SH   SOLE   0 0 0
VERSARTIS INC COM 92529L102 31,363 2,835,754 SH   SOLE   0 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 11,183 130,000 SH   SOLE   0 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 7 650 SH   SOLE   0 0 0
VWR CORP COM 91843L103 539 18,657 SH   SOLE   0 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 10,812 522,595 SH   SOLE   0 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 542 5,056 SH   SOLE   0 0 0
WISDOMTREE EUROPE HEDGED EQU EUROPE HEDGED EQ 97717X701 10,106 200,000 SH Put SOLE   0 0 0
XENCOR INC COM 98401F105 29,046 1,529,574 SH   SOLE   0 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,553 432,800 SH   SOLE   0 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 72 2,638 SH   SOLE   0 0 0
ZIOPHARM ONCOLOGY INC COM 98973P101 5 1,000 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 5,818 849,350 SH   SOLE   0 0 0